======= IGF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGF2
  * **<color #00a2e8>Official Name</color>**: insulin like growth factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3481|3481]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01344|P01344]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IGF2 C|
|Insulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|
|positive regulation of glycogen (starch) synthase activity|
|exocrine pancreas development|
|regulation of glycogen (starch) synthase activity|
|insulin-like growth factor receptor binding|
|positive regulation of glycogen biosynthetic process|
|positive regulation of glycogen metabolic process|
|regulation of gene expression by genetic imprinting|
|positive regulation of activated T cell proliferation|
|insulin receptor binding|
|positive regulation of insulin receptor signaling pathway|
|genetic imprinting|
|positive regulation of cellular response to insulin stimulus|
|embryonic placenta morphogenesis|
|protein serine/threonine kinase activator activity|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|positive regulation of multicellular organism growth|
|receptor ligand activity|
|regulation of glycogen metabolic process|
|regulation of activated T cell proliferation|
|regulation of polysaccharide biosynthetic process|
|positive regulation of glucose metabolic process|
|exocrine system development|
|regulation of polysaccharide metabolic process|
|positive regulation of mitotic nuclear division|
|positive regulation of cellular carbohydrate metabolic process|
|regulation of insulin receptor signaling pathway|
|regulation of multicellular organism growth|
|positive regulation of nuclear division|
|platelet alpha granule lumen|
|pancreas development|
|regulation of cellular response to insulin stimulus|
|positive regulation of carbohydrate metabolic process|
|embryonic placenta development|
|positive regulation of cell division|
|insulin receptor signaling pathway|
|regulation of carbohydrate biosynthetic process|
|positive regulation of T cell proliferation|
|hormone activity|
|regulation of glucose metabolic process|
|glucose metabolic process|
|osteoblast differentiation|
|platelet degranulation|
|positive regulation of lymphocyte proliferation|
|integrin binding|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|digestive system development|
|regulation of histone modification|
|positive regulation of mitotic cell cycle|
|placenta development|
|regulation of muscle cell differentiation|
|regulation of T cell proliferation|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of mitotic nuclear division|
|regulation of cell division|
|positive regulation of developmental growth|
|regulation of chromatin organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|monosaccharide metabolic process|
|striated muscle cell differentiation|
|positive regulation of T cell activation|
|regulation of carbohydrate metabolic process|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|response to insulin|
|regulation of gene expression, epigenetic|
|muscle cell differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of growth|
|ossification|
|cellular response to peptide hormone stimulus|
|positive regulation of cell cycle process|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|cellular response to peptide|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of chromosome organization|
|positive regulation of lymphocyte activation|
|positive regulation of cell cycle|
|in utero embryonic development|
|response to peptide hormone|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|gland development|
|positive regulation of cell activation|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|embryonic organ development|
|response to peptide|
|carbohydrate metabolic process|
|muscle structure development|
|skeletal system development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of cell adhesion|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|exocytosis|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|response to hormone|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|regulation of transferase activity|
|embryo development|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.85|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8699
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGF2 Expression in NALM6 Cells: 0.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>