======= IGFN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGFN1
  * **<color #00a2e8>Official Name</color>**: immunoglobulin like and fibronectin type III domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91156|91156]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VF2|Q86VF2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGFN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGFN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sarcomere|
|Z disc|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.92|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.84|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.73|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.91|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.94|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd3|PSMD3]]|0.615|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.552|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.542|
|[[:human genes:t:tceb3c|TCEB3C]]|0.534|
|[[:human genes:r:rpl35|RPL35]]|0.528|
|[[:human genes:p:polr2j3|POLR2J3]]|0.524|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.516|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.513|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.513|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.513|
|[[:human genes:p:psmd1|PSMD1]]|0.511|
|[[:human genes:m:mylk3|MYLK3]]|0.51|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.507|
|[[:human genes:n:narfl|NARFL]]|0.503|
|[[:human genes:o:orc1|ORC1]]|0.502|
|[[:human genes:m:mt1e|MT1E]]|0.501|
|[[:human genes:p:pan3|PAN3]]|0.497|
|[[:human genes:p:psmb4|PSMB4]]|0.493|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.491|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.489|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.487|
|[[:human genes:k:kctd17|KCTD17]]|0.486|
|[[:human genes:b:bysl|BYSL]]|0.482|
|[[:human genes:c:cope|COPE]]|0.479|
|[[:human genes:c:chd4|CHD4]]|0.478|
|[[:human genes:r:rps2|RPS2]]|0.475|
|[[:human genes:n:nupl1|NUPL1]]|0.474|
|[[:human genes:s:ssh2|SSH2]]|0.473|
|[[:human genes:s:sf3a1|SF3A1]]|0.473|
|[[:human genes:r:rrm1|RRM1]]|0.472|
|[[:human genes:i:ik|IK]]|0.471|
|[[:human genes:r:rpl6|RPL6]]|0.469|
|[[:human genes:c:chaf1a|CHAF1A]]|0.469|
|[[:human genes:s:supt5h|SUPT5H]]|0.467|
|[[:human genes:p:psma6|PSMA6]]|0.466|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.463|
|[[:human genes:d:dock6|DOCK6]]|0.463|
|[[:human genes:v:vasn|VASN]]|0.463|
|[[:human genes:n:nup93|NUP93]]|0.463|
|[[:human genes:k:kif3c|KIF3C]]|0.462|
|[[:human genes:p:pole|POLE]]|0.461|
|[[:human genes:t:twistnb|TWISTNB]]|0.459|
|[[:human genes:p:psmb2|PSMB2]]|0.458|
|[[:human genes:a:aqr|AQR]]|0.454|
|[[:human genes:c:cbwd5|CBWD5]]|0.452|
|[[:human genes:s:slc4a1|SLC4A1]]|0.452|
|[[:human genes:t:traip|TRAIP]]|0.452|
|[[:human genes:d:ddtl|DDTL]]|0.452|
|[[:human genes:s:smg7|SMG7]]|0.452|
|[[:human genes:p:psma7|PSMA7]]|0.45|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.45|
|[[:human genes:u:upf1|UPF1]]|0.45|
|[[:human genes:e:exosc5|EXOSC5]]|0.449|
|[[:human genes:z:znf541|ZNF541]]|0.449|
|[[:human genes:c:cbwd3|CBWD3]]|0.448|
|[[:human genes:e:exosc4|EXOSC4]]|0.447|
|[[:human genes:s:s1pr4|S1PR4]]|0.446|
|[[:human genes:m:myb|MYB]]|0.446|
|[[:human genes:s:snrpa1|SNRPA1]]|0.444|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.444|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.444|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.443|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.443|
|[[:human genes:s:sema6b|SEMA6B]]|0.443|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.443|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.443|
|[[:human genes:r:rad51|RAD51]]|0.443|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.443|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.442|
|[[:human genes:s:slc6a17|SLC6A17]]|0.442|
|[[:human genes:s:sap30bp|SAP30BP]]|0.441|
|[[:human genes:p:pcf11|PCF11]]|0.44|
|[[:human genes:r:rps12|RPS12]]|0.44|
|[[:human genes:o:orc6|ORC6]]|0.439|
|[[:human genes:f:fam160a1|FAM160A1]]|0.439|
|[[:human genes:p:pola2|POLA2]]|0.438|
|[[:human genes:p:psmc1|PSMC1]]|0.438|
|[[:human genes:s:supt6h|SUPT6H]]|0.438|
|[[:human genes:n:nup54|NUP54]]|0.438|
|[[:human genes:f:fcn2|FCN2]]|0.437|
|[[:human genes:n:nol10|NOL10]]|0.435|
|[[:human genes:c:ccna2|CCNA2]]|0.435|
|[[:human genes:a:ankle1|ANKLE1]]|0.434|
|[[:human genes:c:cdt1|CDT1]]|0.434|
|[[:human genes:c:ctr9|CTR9]]|0.434|
|[[:human genes:n:npipb8|NPIPB8]]|0.433|
|[[:human genes:k:kpnb1|KPNB1]]|0.433|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.432|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.432|
|[[:human genes:s:snrnp70|SNRNP70]]|0.432|
|[[:human genes:c:copb1|COPB1]]|0.431|
|[[:human genes:n:npipb5|NPIPB5]]|0.431|
|[[:human genes:t:tspy8|TSPY8]]|0.431|
|[[:human genes:s:sec13|SEC13]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.43|
|[[:human genes:t:tyms|TYMS]]|0.43|
|[[:human genes:d:disp2|DISP2]]|0.428|
|[[:human genes:c:copg1|COPG1]]|0.428|
|[[:human genes:a:arcn1|ARCN1]]|0.428|
|[[:human genes:s:scaf1|SCAF1]]|0.428|
|[[:human genes:c:cdca3|CDCA3]]|0.426|
|[[:human genes:x:xylt2|XYLT2]]|0.426|
|[[:human genes:a:atxn1|ATXN1]]|0.426|
|[[:human genes:a:aamp|AAMP]]|0.425|
|[[:human genes:r:rrn3|RRN3]]|0.425|
|[[:human genes:p:psmc6|PSMC6]]|0.424|
|[[:human genes:z:znf106|ZNF106]]|0.424|
|[[:human genes:r:rnf4|RNF4]]|0.424|
|[[:human genes:p:psma1|PSMA1]]|0.424|
|[[:human genes:r:rad21|RAD21]]|0.423|
|[[:human genes:p:psmb1|PSMB1]]|0.423|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.423|
|[[:human genes:c:ctage4|CTAGE4]]|0.422|
|[[:human genes:s:sart1|SART1]]|0.422|
|[[:human genes:n:npipb11|NPIPB11]]|0.421|
|[[:human genes:o:ogfr|OGFR]]|0.421|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.42|
|[[:human genes:h:hap1|HAP1]]|0.42|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.419|
|[[:human genes:l:lrr1|LRR1]]|0.419|
|[[:human genes:n:naaladl1|NAALADL1]]|0.418|
|[[:human genes:c:cbwd6|CBWD6]]|0.417|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.416|
|[[:human genes:e:exosc9|EXOSC9]]|0.416|
|[[:human genes:c:cactin|CACTIN]]|0.415|
|[[:human genes:z:zfand5|ZFAND5]]|0.415|
|[[:human genes:p:polr2d|POLR2D]]|0.414|
|[[:human genes:u:utp3|UTP3]]|0.414|
|[[:human genes:t:tfip11|TFIP11]]|0.412|
|[[:human genes:u:uqcrh|UQCRH]]|0.412|
|[[:human genes:r:rps7|RPS7]]|0.412|
|[[:human genes:a:ankle2|ANKLE2]]|0.412|
|[[:human genes:d:dido1|DIDO1]]|0.41|
|[[:human genes:c:cdc6|CDC6]]|0.41|
|[[:human genes:p:polr2j2|POLR2J2]]|0.41|
|[[:human genes:p:psmc2|PSMC2]]|0.409|
|[[:human genes:n:nup160|NUP160]]|0.409|
|[[:human genes:p:prim1|PRIM1]]|0.409|
|[[:human genes:a:atp13a1|ATP13A1]]|0.408|
|[[:human genes:d:dtl|DTL]]|0.408|
|[[:human genes:r:rfpl3|RFPL3]]|0.408|
|[[:human genes:s:stil|STIL]]|0.407|
|[[:human genes:p:psmd7|PSMD7]]|0.407|
|[[:human genes:r:rrp15|RRP15]]|0.406|
|[[:human genes:p:psmd11|PSMD11]]|0.406|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.405|
|[[:human genes:s:sfpq|SFPQ]]|0.405|
|[[:human genes:p:plk1|PLK1]]|0.405|
|[[:human genes:c:c2orf27a|C2orf27A]]|0.405|
|[[:human genes:g:golga6a|GOLGA6A]]|0.405|
|[[:human genes:w:wdr43|WDR43]]|0.404|
|[[:human genes:m:med17|MED17]]|0.404|
|[[:human genes:b:brd2|BRD2]]|0.403|
|[[:human genes:r:rbbp5|RBBP5]]|0.402|
|[[:human genes:d:ddt|DDT]]|0.402|
|[[:human genes:p:pwp2|PWP2]]|0.402|
|[[:human genes:r:rrp9|RRP9]]|0.402|
|[[:human genes:k:klhl1|KLHL1]]|0.402|
|[[:human genes:c:cdc73|CDC73]]|0.402|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.402|
|[[:human genes:p:pole2|POLE2]]|0.401|
|[[:human genes:c:cdc45|CDC45]]|0.4|
|[[:human genes:a:ahctf1|AHCTF1]]|0.4|
|[[:human genes:p:ppan|PPAN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGFN1 Expression in NALM6 Cells: -3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>