======= IGJ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JCHAIN
  * **<color #00a2e8>Official Name</color>**: joining chain of multimeric IgA and IgM
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3512|3512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01591|P01591]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGJ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGJ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. {ECO:0000250|UniProtKB:P01592}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dimeric IgA immunoglobulin complex|
|hexameric IgM immunoglobulin complex|
|pentameric IgM immunoglobulin complex|
|secretory dimeric IgA immunoglobulin complex|
|IgA binding|
|monomeric IgA immunoglobulin complex|
|secretory IgA immunoglobulin complex|
|positive regulation of respiratory burst|
|glomerular filtration|
|renal filtration|
|regulation of respiratory burst|
|peptidoglycan binding|
|positive regulation of protein oligomerization|
|phosphatidylcholine binding|
|antibacterial humoral response|
|regulation of protein oligomerization|
|retina homeostasis|
|protein binding, bridging|
|immunoglobulin receptor binding|
|single-stranded DNA binding|
|renal system process|
|antimicrobial humoral response|
|blood microparticle|
|antigen binding|
|tissue homeostasis|
|receptor-mediated endocytosis|
|positive regulation of protein complex assembly|
|multicellular organismal homeostasis|
|defense response to bacterium|
|anatomical structure homeostasis|
|humoral immune response|
|leukocyte migration|
|regulation of protein complex assembly|
|positive regulation of cellular component biogenesis|
|endocytosis|
|adaptive immune response|
|import into cell|
|response to bacterium|
|innate immune response|
|protein homodimerization activity|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|cell motility|
|localization of cell|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|movement of cell or subcellular component|
|extracellular space|
|homeostatic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.86|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18934
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGJ Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>