======= IK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IK
  * **<color #00a2e8>Official Name</color>**: IK cytokine
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3550|3550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13123|Q13123]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600549|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RED C|
|RED N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to kinetochore|
|protein localization to chromosome, centromeric region|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|mitotic spindle pole|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|nuclear chromosome|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|U2-type precatalytic spliceosome|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|protein localization to chromosome|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|negative regulation of chromosome organization|
|mitotic cell cycle checkpoint|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|RNA splicing|
|nuclear speck|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|mRNA processing|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|mRNA metabolic process|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|cell cycle process|
|identical protein binding|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|cellular protein localization|
|cellular macromolecule localization|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.85|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.77|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.86|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.87|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|2.24|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.545|
|[[:human genes:c:cep192|CEP192]]|0.544|
|[[:human genes:p:psmb4|PSMB4]]|0.543|
|[[:human genes:t:tfip11|TFIP11]]|0.541|
|[[:human genes:c:cdca3|CDCA3]]|0.532|
|[[:human genes:v:vps28|VPS28]]|0.532|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.527|
|[[:human genes:c:cbwd3|CBWD3]]|0.526|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.526|
|[[:human genes:n:nsf|NSF]]|0.524|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.522|
|[[:human genes:s:sap30bp|SAP30BP]]|0.52|
|[[:human genes:a:aatf|AATF]]|0.519|
|[[:human genes:c:chd4|CHD4]]|0.518|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.516|
|[[:human genes:c:col2a1|COL2A1]]|0.514|
|[[:human genes:s:supt5h|SUPT5H]]|0.513|
|[[:human genes:r:rpl35|RPL35]]|0.513|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.513|
|[[:human genes:c:cbwd5|CBWD5]]|0.51|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.509|
|[[:human genes:c:cbwd6|CBWD6]]|0.508|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.507|
|[[:human genes:p:prpf19|PRPF19]]|0.507|
|[[:human genes:n:npipb5|NPIPB5]]|0.505|
|[[:human genes:t:tspy8|TSPY8]]|0.504|
|[[:human genes:t:twistnb|TWISTNB]]|0.501|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.499|
|[[:human genes:n:narfl|NARFL]]|0.499|
|[[:human genes:u:utp3|UTP3]]|0.497|
|[[:human genes:s:snip1|SNIP1]]|0.497|
|[[:human genes:t:ticrr|TICRR]]|0.496|
|[[:human genes:a:aamp|AAMP]]|0.495|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.493|
|[[:human genes:p:pan3|PAN3]]|0.492|
|[[:human genes:x:xylt2|XYLT2]]|0.49|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.488|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.488|
|[[:human genes:s:slc4a1|SLC4A1]]|0.488|
|[[:human genes:e:exosc9|EXOSC9]]|0.488|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.488|
|[[:human genes:c:chmp4b|CHMP4B]]|0.487|
|[[:human genes:o:osbp|OSBP]]|0.487|
|[[:human genes:c:chaf1a|CHAF1A]]|0.487|
|[[:human genes:p:polr2j3|POLR2J3]]|0.486|
|[[:human genes:p:psma6|PSMA6]]|0.486|
|[[:human genes:p:plekha4|PLEKHA4]]|0.486|
|[[:human genes:l:lrr1|LRR1]]|0.485|
|[[:human genes:p:psmd7|PSMD7]]|0.484|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.484|
|[[:human genes:f:fam231c|FAM231C]]|0.484|
|[[:human genes:f:fam231a|FAM231A]]|0.484|
|[[:human genes:r:rps12|RPS12]]|0.483|
|[[:human genes:c:cdc45|CDC45]]|0.482|
|[[:human genes:o:orc1|ORC1]]|0.482|
|[[:human genes:r:rrp7a|RRP7A]]|0.481|
|[[:human genes:a:akirin2|AKIRIN2]]|0.477|
|[[:human genes:p:paf1|PAF1]]|0.477|
|[[:human genes:v:vasn|VASN]]|0.476|
|[[:human genes:k:krt78|KRT78]]|0.474|
|[[:human genes:d:ddtl|DDTL]]|0.473|
|[[:human genes:p:pole|POLE]]|0.472|
|[[:human genes:i:igfn1|IGFN1]]|0.471|
|[[:human genes:p:ppfia4|PPFIA4]]|0.471|
|[[:human genes:w:wapal|WAPAL]]|0.471|
|[[:human genes:t:tyms|TYMS]]|0.471|
|[[:human genes:s:slc6a17|SLC6A17]]|0.471|
|[[:human genes:p:psmb3|PSMB3]]|0.47|
|[[:human genes:c:c14orf93|C14orf93]]|0.47|
|[[:human genes:g:gar1|GAR1]]|0.469|
|[[:human genes:k:kctd17|KCTD17]]|0.469|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.469|
|[[:human genes:r:rps7|RPS7]]|0.469|
|[[:human genes:p:pan2|PAN2]]|0.468|
|[[:human genes:c:ccna2|CCNA2]]|0.468|
|[[:human genes:r:rad51|RAD51]]|0.467|
|[[:human genes:a:ankle1|ANKLE1]]|0.466|
|[[:human genes:c:cln6|CLN6]]|0.466|
|[[:human genes:p:pdcd7|PDCD7]]|0.466|
|[[:human genes:f:fcn2|FCN2]]|0.465|
|[[:human genes:o:orc6|ORC6]]|0.464|
|[[:human genes:m:mt1e|MT1E]]|0.461|
|[[:human genes:w:wdr75|WDR75]]|0.458|
|[[:human genes:a:akt1s1|AKT1S1]]|0.458|
|[[:human genes:z:zfand5|ZFAND5]]|0.457|
|[[:human genes:n:naaladl1|NAALADL1]]|0.456|
|[[:human genes:z:znf830|ZNF830]]|0.455|
|[[:human genes:o:or10g3|OR10G3]]|0.453|
|[[:human genes:a:acsf2|ACSF2]]|0.453|
|[[:human genes:r:rrn3|RRN3]]|0.451|
|[[:human genes:d:dock6|DOCK6]]|0.45|
|[[:human genes:t:timeless|TIMELESS]]|0.45|
|[[:human genes:r:ranbp2|RANBP2]]|0.449|
|[[:human genes:a:ankle2|ANKLE2]]|0.449|
|[[:human genes:n:nupl1|NUPL1]]|0.449|
|[[:human genes:r:rnpc3|RNPC3]]|0.448|
|[[:human genes:c:ctage4|CTAGE4]]|0.447|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.446|
|[[:human genes:e:exosc3|EXOSC3]]|0.446|
|[[:human genes:p:psmc2|PSMC2]]|0.445|
|[[:human genes:n:nol10|NOL10]]|0.445|
|[[:human genes:s:snrpf|SNRPF]]|0.445|
|[[:human genes:p:pcf11|PCF11]]|0.444|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.444|
|[[:human genes:d:disp2|DISP2]]|0.444|
|[[:human genes:r:rad21|RAD21]]|0.443|
|[[:human genes:a:aqr|AQR]]|0.443|
|[[:human genes:c:cdt1|CDT1]]|0.443|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.441|
|[[:human genes:e:exosc6|EXOSC6]]|0.44|
|[[:human genes:c:cactin|CACTIN]]|0.44|
|[[:human genes:p:psmb2|PSMB2]]|0.439|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.439|
|[[:human genes:s:smg7|SMG7]]|0.438|
|[[:human genes:p:polr2d|POLR2D]]|0.438|
|[[:human genes:u:upf1|UPF1]]|0.438|
|[[:human genes:p:pno1|PNO1]]|0.438|
|[[:human genes:n:nup153|NUP153]]|0.436|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.435|
|[[:human genes:r:rps19|RPS19]]|0.435|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.435|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.434|
|[[:human genes:d:dtl|DTL]]|0.434|
|[[:human genes:s:supt6h|SUPT6H]]|0.434|
|[[:human genes:p:pola2|POLA2]]|0.433|
|[[:human genes:p:polr2a|POLR2A]]|0.432|
|[[:human genes:g:golga8o|GOLGA8O]]|0.431|
|[[:human genes:r:rbm8a|RBM8A]]|0.43|
|[[:human genes:t:tinf2|TINF2]]|0.429|
|[[:human genes:b:bysl|BYSL]]|0.429|
|[[:human genes:c:cdh24|CDH24]]|0.428|
|[[:human genes:s:snrnp70|SNRNP70]]|0.427|
|[[:human genes:s:snrpa1|SNRPA1]]|0.426|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.425|
|[[:human genes:c:cdc6|CDC6]]|0.425|
|[[:human genes:p:polr1a|POLR1A]]|0.425|
|[[:human genes:d:dhx38|DHX38]]|0.425|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.425|
|[[:human genes:c:copg1|COPG1]]|0.424|
|[[:human genes:m:mdn1|MDN1]]|0.424|
|[[:human genes:p:parp3|PARP3]]|0.423|
|[[:human genes:l:lad1|LAD1]]|0.423|
|[[:human genes:w:wdr43|WDR43]]|0.423|
|[[:human genes:r:rps2|RPS2]]|0.423|
|[[:human genes:s:sf3a1|SF3A1]]|0.422|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.422|
|[[:human genes:a:adrm1|ADRM1]]|0.422|
|[[:human genes:e:exosc8|EXOSC8]]|0.421|
|[[:human genes:h:hivep3|HIVEP3]]|0.421|
|[[:human genes:s:smg1|SMG1]]|0.42|
|[[:human genes:m:mbtd1|MBTD1]]|0.419|
|[[:human genes:e:eif4a3|EIF4A3]]|0.419|
|[[:human genes:n:noc4l|NOC4L]]|0.419|
|[[:human genes:r:rps9|RPS9]]|0.418|
|[[:human genes:r:rbm39|RBM39]]|0.417|
|[[:human genes:r:rplp1|RPLP1]]|0.417|
|[[:human genes:m:mtch2|MTCH2]]|0.417|
|[[:human genes:c:copb1|COPB1]]|0.417|
|[[:human genes:p:ppie|PPIE]]|0.417|
|[[:human genes:u:ubl5|UBL5]]|0.415|
|[[:human genes:f:fbxw9|FBXW9]]|0.415|
|[[:human genes:a:aurka|AURKA]]|0.415|
|[[:human genes:n:nipbl|NIPBL]]|0.415|
|[[:human genes:i:ints5|INTS5]]|0.415|
|[[:human genes:p:pdcd11|PDCD11]]|0.415|
|[[:human genes:m:myo1h|MYO1H]]|0.415|
|[[:human genes:g:gid4|GID4]]|0.415|
|[[:human genes:g:golga6a|GOLGA6A]]|0.415|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.414|
|[[:human genes:c:cdca5|CDCA5]]|0.414|
|[[:human genes:c:cdc73|CDC73]]|0.413|
|[[:human genes:i:ints1|INTS1]]|0.413|
|[[:human genes:f:fam25b|FAM25B]]|0.413|
|[[:human genes:t:tuba8|TUBA8]]|0.412|
|[[:human genes:f:foxd4l2|FOXD4L2]]|0.411|
|[[:human genes:r:rffl|RFFL]]|0.411|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.411|
|[[:human genes:r:rrp15|RRP15]]|0.41|
|[[:human genes:s:syt9|SYT9]]|0.41|
|[[:human genes:r:rpl6|RPL6]]|0.409|
|[[:human genes:r:rrs1|RRS1]]|0.409|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.409|
|[[:human genes:c:ccdc94|CCDC94]]|0.409|
|[[:human genes:p:psmc1|PSMC1]]|0.408|
|[[:human genes:c:ccdc116|CCDC116]]|0.408|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.408|
|[[:human genes:a:arcn1|ARCN1]]|0.407|
|[[:human genes:e:exd1|EXD1]]|0.406|
|[[:human genes:d:ddx56|DDX56]]|0.406|
|[[:human genes:r:rpl14|RPL14]]|0.405|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.405|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.405|
|[[:human genes:c:ccdc12|CCDC12]]|0.405|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.405|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.405|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.404|
|[[:human genes:p:psmd11|PSMD11]]|0.404|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.404|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.404|
|[[:human genes:s:stil|STIL]]|0.404|
|[[:human genes:e:egr2|EGR2]]|0.403|
|[[:human genes:t:terf1|TERF1]]|0.403|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.403|
|[[:human genes:c:clec11a|CLEC11A]]|0.402|
|[[:human genes:e:exosc5|EXOSC5]]|0.402|
|[[:human genes:r:rrm2|RRM2]]|0.401|
|[[:human genes:s:sf3a2|SF3A2]]|0.401|
|[[:human genes:p:ppm1d|PPM1D]]|0.4|
|[[:human genes:f:fam160a1|FAM160A1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 700/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|23/26|
|breast|28/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|18/21|
|liver|20/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1228
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IK Expression in NALM6 Cells: 6.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>