======= IL15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL15
  * **<color #00a2e8>Official Name</color>**: interleukin 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3600|3600]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40933|P40933]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600554|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL15|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrathymic T cell selection|
|extrathymic T cell differentiation|
|NK T cell activation|
|NK T cell proliferation|
|positive regulation of protein O-linked glycosylation|
|alpha-beta T cell proliferation|
|regulation of protein O-linked glycosylation|
|positive regulation of natural killer cell proliferation|
|skeletal muscle atrophy|
|positive regulation of natural killer cell differentiation|
|striated muscle atrophy|
|tyrosine phosphorylation of STAT protein|
|muscle atrophy|
|regulation of natural killer cell proliferation|
|positive regulation of protein glycosylation|
|cytokine receptor binding|
|skeletal muscle adaptation|
|interleukin-15-mediated signaling pathway|
|regulation of natural killer cell differentiation|
|cellular response to interleukin-15|
|regulation of protein glycosylation|
|response to interleukin-15|
|cellular response to vitamin D|
|positive regulation of interleukin-17 production|
|lymph node development|
|positive regulation of natural killer cell activation|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of glycoprotein metabolic process|
|macrophage differentiation|
|cellular response to vitamin|
|striated muscle adaptation|
|regulation of interleukin-17 production|
|response to vitamin D|
|positive regulation of tissue remodeling|
|hyaluronan metabolic process|
|muscle adaptation|
|regulation of natural killer cell activation|
|regulation of defense response to virus by host|
|receptor signaling pathway via JAK-STAT|
|T cell proliferation|
|receptor signaling pathway via STAT|
|T cell selection|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|negative regulation of smooth muscle cell proliferation|
|negative regulation of cold-induced thermogenesis|
|alpha-beta T cell activation|
|cellular response to nutrient|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of phagocytosis|
|regulation of tissue remodeling|
|regulation of defense response to virus|
|regulation of tyrosine phosphorylation of STAT protein|
|lymphocyte proliferation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|mononuclear cell proliferation|
|response to vitamin|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|regulation of phagocytosis|
|leukocyte proliferation|
|mucopolysaccharide metabolic process|
|myeloid leukocyte differentiation|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of inflammatory response|
|peptidyl-tyrosine phosphorylation|
|regulation of cold-induced thermogenesis|
|positive regulation of leukocyte differentiation|
|peptidyl-tyrosine modification|
|glycosaminoglycan metabolic process|
|regulation of T cell proliferation|
|cell maturation|
|aminoglycan metabolic process|
|regulation of lymphocyte differentiation|
|cytokine activity|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|cellular response to nutrient levels|
|T cell activation|
|lymphocyte differentiation|
|developmental maturation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|cellular response to extracellular stimulus|
|endosome|
|regulation of leukocyte differentiation|
|aging|
|regulation of leukocyte cell-cell adhesion|
|muscle system process|
|regulation of T cell activation|
|leukocyte differentiation|
|cellular response to external stimulus|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|nuclear speck|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|positive regulation of defense response|
|inflammatory response|
|response to nutrient levels|
|neutrophil activation|
|granulocyte activation|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|hemopoiesis|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|regulation of multi-organism process|
|response to lipid|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|positive regulation of cell differentiation|
|protein phosphorylation|
|Golgi apparatus|
|positive regulation of transport|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|phosphorylation|
|defense response|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.25|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17959
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL15 Expression in NALM6 Cells: 1.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>