======= IL16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL16
  * **<color #00a2e8>Official Name</color>**: interleukin 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3603|3603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14005|Q14005]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD4 receptor binding|
|induction of positive chemotaxis|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|positive regulation of chemotaxis|
|leukocyte chemotaxis|
|cytokine activity|
|cell chemotaxis|
|regulation of chemotaxis|
|regulation of calcium ion transport|
|leukocyte migration|
|regulation of metal ion transport|
|nuclear speck|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|cytokine-mediated signaling pathway|
|regulation of ion transport|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cell migration|
|regulation of locomotion|
|cellular response to cytokine stimulus|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|locomotion|
|movement of cell or subcellular component|
|extracellular space|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.58|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6050
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL16 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>