======= IL17RC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL17RC
  * **<color #00a2e8>Official Name</color>**: interleukin 17 receptor C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84818|84818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NAC3|Q8NAC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL17RC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL17RC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610925|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SEFIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-17 receptor activity|
|response to interleukin-17|
|cellular response to interleukin-17|
|interleukin-17-mediated signaling pathway|
|positive regulation of cytokine production involved in inflammatory response|
|positive regulation of interleukin-6 secretion|
|defense response to fungus|
|regulation of cytokine production involved in inflammatory response|
|response to fungus|
|granulocyte chemotaxis|
|positive regulation of interleukin-6 production|
|granulocyte migration|
|myeloid leukocyte migration|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|leukocyte chemotaxis|
|regulation of cytokine secretion|
|cell chemotaxis|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|signaling receptor binding|
|regulation of inflammatory response|
|leukocyte migration|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|chemotaxis|
|taxis|
|positive regulation of response to external stimulus|
|cell surface|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|movement of cell or subcellular component|
|positive regulation of multicellular organismal process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL17RC Expression in NALM6 Cells: 2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>