======= IL1B =======
== Gene Information ==
* **Official Symbol**: IL1B
* **Official Name**: interleukin 1 beta
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3553|3553]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P01584|P01584]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=IL1B&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1B|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/147720|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. {ECO:0000269|PubMed:3920526}.
|IL1 propep|
|IL1|
|regulation of myosin light chain kinase activity|
|positive regulation of myosin light chain kinase activity|
|positive regulation of calcidiol 1-monooxygenase activity|
|monocyte aggregation|
|positive regulation of vitamin D biosynthetic process|
|fever generation|
|positive regulation of cell adhesion molecule production|
|smooth muscle adaptation|
|negative regulation of adiponectin secretion|
|positive regulation of complement activation|
|positive regulation of vitamin metabolic process|
|sequestering of triglyceride|
|regulation of T-helper 1 cell cytokine production|
|positive regulation of T-helper 1 cell cytokine production|
|heat generation|
|regulation of cell adhesion molecule production|
|regulation of adiponectin secretion|
|positive regulation of prostaglandin biosynthetic process|
|hyaluronan biosynthetic process|
|positive regulation of fever generation|
|regulation of calcidiol 1-monooxygenase activity|
|ectopic germ cell programmed cell death|
|regulation of fever generation|
|positive regulation of histone phosphorylation|
|positive regulation of unsaturated fatty acid biosynthetic process|
|regulation of prostaglandin biosynthetic process|
|regulation of vitamin D biosynthetic process|
|programmed cell death involved in cell development|
|positive regulation of monocyte chemotactic protein-1 production|
|leukocyte aggregation|
|positive regulation of prostaglandin secretion|
|regulation of unsaturated fatty acid biosynthetic process|
|positive regulation of hormone biosynthetic process|
|regulation of prostaglandin secretion|
|positive regulation of heat generation|
|interleukin-6 production|
|positive regulation of chemokine biosynthetic process|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of vitamin metabolic process|
|regulation of histone phosphorylation|
|regulation of heat generation|
|positive regulation of interleukin-2 biosynthetic process|
|regulation of establishment of endothelial barrier|
|regulation of endothelial cell development|
|interleukin-1 receptor binding|
|positive regulation of neuroinflammatory response|
|positive regulation of hormone metabolic process|
|positive regulation of glial cell proliferation|
|interleukin-1 beta production|
|positive regulation of membrane protein ectodomain proteolysis|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of interleukin-6 biosynthetic process|
|regulation of chemokine biosynthetic process|
|positive regulation of heterotypic cell-cell adhesion|
|regulation of monocyte chemotactic protein-1 production|
|positive regulation of icosanoid secretion|
|interleukin-1 production|
|positive regulation of humoral immune response|
|negative regulation of glucose transmembrane transport|
|positive regulation of steroid biosynthetic process|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|astrocyte activation|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of fatty acid biosynthetic process|
|positive regulation of T cell cytokine production|
|positive regulation of T-helper 1 type immune response|
|positive regulation of protein export from nucleus|
|negative regulation of lipid catabolic process|
|regulation of membrane protein ectodomain proteolysis|
|regulation of interleukin-6 biosynthetic process|
|positive regulation of lipid catabolic process|
|positive regulation of alcohol biosynthetic process|
|regulation of heterotypic cell-cell adhesion|
|positive regulation of steroid metabolic process|
|regulation of hormone biosynthetic process|
|positive regulation of p38MAPK cascade|
|regulation of T-helper 1 type immune response|
|regulation of fatty acid transport|
|positive regulation of monooxygenase activity|
|positive regulation of vascular endothelial growth factor production|
|lipid storage|
|positive regulation of acute inflammatory response|
|positive regulation of histone acetylation|
|temperature homeostasis|
|regulation of glial cell proliferation|
|positive regulation of interleukin-2 production|
|regulation of T cell cytokine production|
|response to ATP|
|extrinsic apoptotic signaling pathway in absence of ligand|
|regulation of neuroinflammatory response|
|hyaluronan metabolic process|
|signal transduction in absence of ligand|
|positive regulation of interleukin-6 secretion|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of vascular endothelial growth factor production|
|muscle adaptation|
|positive regulation of peptidyl-lysine acetylation|
|regulation of endothelial cell differentiation|
|positive regulation of fatty acid metabolic process|
|negative regulation of insulin receptor signaling pathway|
|lipopolysaccharide-mediated signaling pathway|
|positive regulation of organic acid transport|
|negative regulation of signal transduction in absence of ligand|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|astrocyte development|
|negative regulation of cellular response to insulin stimulus|
|embryo implantation|
|regulation of defense response to virus by host|
|regulation of hormone metabolic process|
|protein kinase B signaling|
|glial cell activation|
|regulation of protein export from nucleus|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|acute-phase response|
|regulation of p38MAPK cascade|
|neuroinflammatory response|
|positive regulation of protein acetylation|
|regulation of endocrine process|
|regulation of acute inflammatory response|
|regulation of nitric-oxide synthase activity|
|regulation of fatty acid biosynthetic process|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of epithelial to mesenchymal transition|
|positive regulation of T cell mediated immunity|
|positive regulation of interleukin-8 production|
|leukocyte cell-cell adhesion|
|positive regulation of anion transport|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of mitotic nuclear division|
|astrocyte differentiation|
|positive regulation of oxidoreductase activity|
|regulation of interleukin-2 production|
|regulation of monooxygenase activity|
|positive regulation of cytokine production involved in immune response|
|regulation of lipid catabolic process|
|regulation of nitric oxide biosynthetic process|
|regulation of histone acetylation|
|positive regulation of chemokine production|
|regulation of organic acid transport|
|positive regulation of lipid transport|
|negative regulation of synaptic transmission|
|regulation of peptidyl-lysine acetylation|
|positive regulation of nucleocytoplasmic transport|
|negative regulation of hormone secretion|
|regulation of insulin receptor signaling pathway|
|positive regulation of interferon-gamma production|
|positive regulation of nuclear division|
|positive regulation of cytokine biosynthetic process|
|positive regulation of phagocytosis|
|positive regulation of gliogenesis|
|regulation of interleukin-8 production|
|regulation of T cell mediated immunity|
|acute inflammatory response|
|regulation of protein acetylation|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|regulation of defense response to virus|
|negative regulation of MAP kinase activity|
|regulation of alcohol biosynthetic process|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of chemokine production|
|positive regulation of lipid biosynthetic process|
|cellular response to mechanical stimulus|
|positive regulation of lipid localization|
|neutrophil chemotaxis|
|negative regulation of lipid metabolic process|
|regulation of epithelial to mesenchymal transition|
|regulation of cytokine production involved in immune response|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of cell division|
|regulation of fatty acid metabolic process|
|secretory granule|
|regulation of steroid biosynthetic process|
|granulocyte chemotaxis|
|positive regulation of histone modification|
|neutrophil migration|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|regulation of anion transport|
|positive regulation of reactive oxygen species metabolic process|
|regulation of phagocytosis|
|interleukin-1-mediated signaling pathway|
|regulation of oxidoreductase activity|
|extrinsic apoptotic signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|granulocyte migration|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of extrinsic apoptotic signaling pathway|
|glycosaminoglycan biosynthetic process|
|positive regulation of chromatin organization|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|regulation of cytokine biosynthetic process|
|regulation of nucleocytoplasmic transport|
|mucopolysaccharide metabolic process|
|glial cell development|
|regulation of lipid transport|
|aminoglycan biosynthetic process|
|regulation of NIK/NF-kappaB signaling|
|regulation of steroid metabolic process|
|regulation of gliogenesis|
|negative regulation of transmembrane transport|
|regulation of complement activation|
|myeloid leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|integrin binding|
|negative regulation of protein secretion|
|positive regulation of leukocyte mediated immunity|
|negative regulation of protein serine/threonine kinase activity|
|response to organophosphorus|
|regulation of humoral immune response|
|positive regulation of leukocyte proliferation|
|positive regulation of small molecule metabolic process|
|regulation of lipid localization|
|positive regulation of cytokine secretion|
|positive regulation of JNK cascade|
|negative regulation of peptide secretion|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of epithelial cell differentiation|
|positive regulation of lipid metabolic process|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|regulation of histone modification|
|cytokine production|
|regulation of lymphocyte mediated immunity|
|positive regulation of mitotic cell cycle|
|positive regulation of NF-kappaB transcription factor activity|
|response to purine-containing compound|
|positive regulation of intracellular protein transport|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|glycosaminoglycan metabolic process|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|positive regulation of angiogenesis|
|maintenance of location|
|aminoglycan metabolic process|
|negative regulation of MAPK cascade|
|positive regulation of stress-activated MAPK cascade|
|regulation of cell division|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of mitotic nuclear division|
|glial cell differentiation|
|response to carbohydrate|
|regulation of cellular ketone metabolic process|
|cytokine activity|
|positive regulation of chromosome organization|
|cellular response to interleukin-1|
|regulation of insulin secretion|
|regulation of reactive oxygen species metabolic process|
|female pregnancy|
|negative regulation of protein transport|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to lipopolysaccharide|
|negative regulation of establishment of protein localization|
|regulation of JNK cascade|
|regulation of lipid biosynthetic process|
|regulation of chromatin organization|
|cellular response to molecule of bacterial origin|
|regulation of nuclear division|
|response to interleukin-1|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|response to mechanical stimulus|
|gliogenesis|
|cellular response to biotic stimulus|
|response to nutrient|
|positive regulation of protein catabolic process|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|negative regulation of apoptotic signaling pathway|
|negative regulation of protein kinase activity|
|regulation of intracellular protein transport|
|negative regulation of secretion|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|protein domain specific binding|
|negative regulation of kinase activity|
|lysosome|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of leukocyte cell-cell adhesion|
|muscle system process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to lipopolysaccharide|
|regulation of T cell activation|
|lipid localization|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|negative regulation of cell development|
|cellular response to external stimulus|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of chromosome organization|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|positive regulation of cell cycle|
|leukocyte migration|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|response to nutrient levels|
|inflammatory response|
|positive regulation of cell migration|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|taxis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|organic acid metabolic process|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.82|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.11|
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.405|
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 14184
* **Expression level (log2 read counts)**: -0.81
{{:chemogenomics:nalm6 dist.png?nolink |}}