======= IL1RAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1RAP
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor accessory protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3556|3556]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPH3|Q9NPH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1RAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1RAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602626|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:19836339}. Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-33 receptor activity|
|interleukin-33-mediated signaling pathway|
|interleukin-2 biosynthetic process|
|interleukin-4 secretion|
|interleukin-1 receptor activity|
|interleukin-4 production|
|trans-synaptic signaling by trans-synaptic complex|
|interleukin-2 production|
|regulation of postsynaptic density assembly|
|regulation of postsynapse assembly|
|regulation of postsynaptic specialization assembly|
|positive regulation of interleukin-5 production|
|interleukin-1 receptor binding|
|regulation of excitatory synapse assembly|
|cytokine biosynthetic process|
|regulation of postsynaptic density organization|
|cytokine metabolic process|
|positive regulation of interleukin-13 production|
|regulation of interleukin-13 production|
|regulation of interleukin-5 production|
|synaptic membrane adhesion|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|positive regulation of interleukin-6 secretion|
|cytokine secretion|
|positive regulation of synapse assembly|
|positive regulation of interleukin-6 production|
|interleukin-1-mediated signaling pathway|
|regulation of postsynapse organization|
|regulation of synapse assembly|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|cellular response to interleukin-1|
|response to interleukin-1|
|regulation of cytokine secretion|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|positive regulation of DNA-binding transcription factor activity|
|synapse organization|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|glutamatergic synapse|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|trans-synaptic signaling|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|regulation of peptide secretion|
|inflammatory response|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|regulation of secretion|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.05|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1RAP Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>