======= IL1RL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1RL1
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9173|9173]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01638|Q01638]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1RL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1RL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. {ECO:0000269|PubMed:16286016, ECO:0000305|PubMed:19836339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-33 binding|
|interleukin-33 receptor activity|
|interleukin-33-mediated signaling pathway|
|interleukin-1 receptor activity|
|negative regulation of T-helper 1 type immune response|
|positive regulation of interleukin-5 production|
|positive regulation of chemokine secretion|
|regulation of chemokine secretion|
|regulation of interleukin-5 production|
|positive regulation of macrophage activation|
|regulation of T-helper 1 type immune response|
|negative regulation of interferon-gamma production|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of adaptive immune response|
|cytokine receptor activity|
|regulation of macrophage activation|
|positive regulation of chemokine production|
|regulation of chemokine production|
|regulation of interferon-gamma production|
|positive regulation of cytokine secretion|
|positive regulation of inflammatory response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of adaptive immune response|
|regulation of cytokine secretion|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of inflammatory response|
|external side of plasma membrane|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.77|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.7|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17761
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1RL1 Expression in NALM6 Cells: 0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>