======= IL2RB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL2RB
  * **<color #00a2e8>Official Name</color>**: interleukin 2 receptor subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3560|3560]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14784|P14784]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL2RB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL2RB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-2 receptor complex|
|interleukin-2 receptor activity|
|interleukin-2 binding|
|interleukin-15 receptor activity|
|interleukin-2-mediated signaling pathway|
|cellular response to interleukin-2|
|response to interleukin-2|
|interleukin-15-mediated signaling pathway|
|cellular response to interleukin-15|
|response to interleukin-15|
|positive regulation of phagocytosis|
|regulation of phagocytosis|
|endosome|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of vesicle-mediated transport|
|cell surface|
|cytokine-mediated signaling pathway|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|response to cytokine|
|phosphorylation|
|integral component of plasma membrane|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.492|
|[[:human genes:v:vps28|VPS28]]|0.43|
|[[:human genes:p:psmb2|PSMB2]]|0.403|
|[[:human genes:d:ddx56|DDX56]]|0.402|
|[[:human genes:e:exosc9|EXOSC9]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2985
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL2RB Expression in NALM6 Cells: -0.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>