======= IL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL6
  * **<color #00a2e8>Official Name</color>**: interleukin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3569|3569]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05231|P05231]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucagon secretion|
|regulation of interleukin-17 biosynthetic process|
|regulation of maintenance of permeability of blood-brain barrier|
|positive regulation of interleukin-17 biosynthetic process|
|neutrophil apoptotic process|
|hepatic immune response|
|interleukin-6 receptor complex|
|negative regulation of chemokine biosynthetic process|
|positive regulation of type B pancreatic cell apoptotic process|
|regulation of astrocyte activation|
|positive regulation of apoptotic DNA fragmentation|
|myeloid cell apoptotic process|
|negative regulation of interleukin-1-mediated signaling pathway|
|positive regulation of DNA catabolic process|
|T-helper 17 cell lineage commitment|
|inflammatory cell apoptotic process|
|interleukin-6 receptor binding|
|regulation of interleukin-1-mediated signaling pathway|
|positive regulation of T-helper 2 cell cytokine production|
|T-helper 17 type immune response|
|T-helper 17 cell differentiation|
|positive regulation of extracellular matrix disassembly|
|regulation of type B pancreatic cell apoptotic process|
|negative regulation of collagen biosynthetic process|
|T-helper cell lineage commitment|
|regulation of apoptotic DNA fragmentation|
|CD4-positive, alpha-beta T cell lineage commitment|
|neutrophil homeostasis|
|negative regulation of collagen metabolic process|
|regulation of T-helper 2 cell cytokine production|
|response to peptidoglycan|
|positive regulation of immunoglobulin secretion|
|regulation of DNA catabolic process|
|alpha-beta T cell lineage commitment|
|negative regulation of bone resorption|
|positive regulation of neuroinflammatory response|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|regulation of chemokine biosynthetic process|
|negative regulation of bone remodeling|
|positive regulation of glial cell proliferation|
|positive regulation of execution phase of apoptosis|
|positive regulation of type 2 immune response|
|interleukin-6-mediated signaling pathway|
|regulation of extracellular matrix disassembly|
|positive regulation of interleukin-17 production|
|regulation of microglial cell activation|
|negative regulation of lipid storage|
|regulation of immunoglobulin secretion|
|positive regulation of T cell cytokine production|
|negative regulation of chemokine production|
|negative regulation of tissue remodeling|
|T cell lineage commitment|
|positive regulation of extracellular matrix organization|
|leukocyte apoptotic process|
|positive T cell selection|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|regulation of astrocyte differentiation|
|alpha-beta T cell activation involved in immune response|
|positive regulation of vascular endothelial growth factor production|
|alpha-beta T cell differentiation involved in immune response|
|positive regulation of acute inflammatory response|
|regulation of interleukin-17 production|
|regulation of type 2 immune response|
|regulation of glial cell proliferation|
|regulation of T cell cytokine production|
|regulation of neuroinflammatory response|
|negative regulation of cytokine biosynthetic process|
|cellular response to interleukin-6|
|positive regulation of epithelial cell apoptotic process|
|T cell differentiation involved in immune response|
|organ or tissue specific immune response|
|regulation of vascular endothelial growth factor production|
|CD4-positive, alpha-beta T cell differentiation|
|neuron cellular homeostasis|
|regulation of collagen biosynthetic process|
|response to interleukin-6|
|endocrine pancreas development|
|regulation of extracellular matrix organization|
|CD4-positive, alpha-beta T cell activation|
|T cell selection|
|acute-phase response|
|regulation of collagen metabolic process|
|regulation of bone resorption|
|negative regulation of lipid localization|
|regulation of execution phase of apoptosis|
|monocyte chemotaxis|
|positive regulation of immunoglobulin production|
|regulation of acute inflammatory response|
|regulation of lipid storage|
|negative regulation of fat cell differentiation|
|positive regulation of epithelial to mesenchymal transition|
|regulation of bone remodeling|
|positive regulation of T cell mediated immunity|
|mononuclear cell migration|
|alpha-beta T cell differentiation|
|regulation of macrophage activation|
|positive regulation of cytokine production involved in immune response|
|positive regulation of chemokine production|
|positive regulation of osteoblast differentiation|
|peptide hormone secretion|
|negative regulation of cytokine-mediated signaling pathway|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|regulation of immunoglobulin production|
|negative regulation of response to cytokine stimulus|
|positive regulation of cytokine biosynthetic process|
|positive regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of gliogenesis|
|leukocyte homeostasis|
|regulation of glial cell differentiation|
|acute inflammatory response|
|cellular response to hydrogen peroxide|
|regulation of T cell mediated immunity|
|hormone secretion|
|pancreas development|
|regulation of tissue remodeling|
|regulation of chemokine production|
|regulation of tyrosine phosphorylation of STAT protein|
|regulation of epithelial cell apoptotic process|
|hormone transport|
|regulation of epithelial to mesenchymal transition|
|defense response to Gram-negative bacterium|
|positive regulation of ossification|
|positive regulation of receptor signaling pathway via JAK-STAT|
|regulation of cytokine production involved in immune response|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of leukocyte chemotaxis|
|positive regulation of receptor signaling pathway via STAT|
|defense response to Gram-positive bacterium|
|positive regulation of T cell proliferation|
|positive regulation of interleukin-6 production|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cytokine biosynthetic process|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of peptidyl-serine phosphorylation|
|myeloid cell homeostasis|
|lymphocyte activation involved in immune response|
|regulation of osteoblast differentiation|
|regulation of leukocyte chemotaxis|
|regulation of gliogenesis|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|endocrine system development|
|regulation of fat cell differentiation|
|positive regulation of translation|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|cellular response to reactive oxygen species|
|positive regulation of mononuclear cell proliferation|
|regulation of smooth muscle cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of peptidyl-serine phosphorylation|
|platelet activation|
|regulation of lipid localization|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|response to glucocorticoid|
|regulation of lymphocyte mediated immunity|
|positive regulation of cellular amide metabolic process|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|response to corticosteroid|
|regulation of cytokine-mediated signaling pathway|
|growth factor activity|
|positive regulation of B cell activation|
|signal release|
|cytokine activity|
|peptide secretion|
|regulation of response to cytokine stimulus|
|cellular response to lipopolysaccharide|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of ossification|
|cellular response to molecule of bacterial origin|
|defense response to virus|
|positive regulation of DNA metabolic process|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|regulation of chemotaxis|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|cellular response to oxidative stress|
|cell fate commitment|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of protein secretion|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|blood coagulation|
|coagulation|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|endoplasmic reticulum lumen|
|response to antibiotic|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|regulation of T cell activation|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|response to steroid hormone|
|defense response to bacterium|
|leukocyte differentiation|
|negative regulation of cell development|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|humoral immune response|
|regulation of translation|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|post-translational protein modification|
|positive regulation of cellular catabolic process|
|leukocyte migration|
|lymphocyte activation|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|cellular response to drug|
|positive regulation of leukocyte activation|
|regulation of cellular amide metabolic process|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|wound healing|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|response to toxic substance|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|hemopoiesis|
|response to wounding|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|neuron projection development|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.97|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.93|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.91|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.77|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.76|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.84|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.91|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.14|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.28|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.487|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL6 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>