======= IL7R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL7R
  * **<color #00a2e8>Official Name</color>**: interleukin 7 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3575|3575]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16871|P16871]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL7R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL7R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-7 receptor activity|
|negative regulation of T cell mediated cytotoxicity|
|positive regulation of T cell differentiation in thymus|
|lymph node development|
|negative regulation of leukocyte mediated cytotoxicity|
|negative regulation of T cell apoptotic process|
|negative regulation of T cell mediated immunity|
|interleukin-7-mediated signaling pathway|
|negative regulation of cell killing|
|regulation of T cell differentiation in thymus|
|negative regulation of lymphocyte apoptotic process|
|cellular response to interleukin-7|
|response to interleukin-7|
|regulation of T cell apoptotic process|
|regulation of T cell mediated cytotoxicity|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|B cell proliferation|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte apoptotic process|
|cytokine receptor activity|
|negative regulation of leukocyte mediated immunity|
|regulation of lymphocyte apoptotic process|
|clathrin-coated vesicle membrane|
|regulation of T cell mediated immunity|
|regulation of leukocyte mediated cytotoxicity|
|regulation of leukocyte apoptotic process|
|positive regulation of T cell differentiation|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of lymphocyte differentiation|
|leukocyte proliferation|
|regulation of cell killing|
|regulation of DNA recombination|
|negative regulation of immune effector process|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|regulation of T cell differentiation|
|antigen binding|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|B cell activation|
|immunoglobulin production|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|production of molecular mediator of immune response|
|regulation of cell size|
|positive regulation of hemopoiesis|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|positive regulation of leukocyte cell-cell adhesion|
|T cell activation|
|lymphocyte differentiation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|leukocyte differentiation|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|regulation of cellular component size|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of immune effector process|
|regulation of anatomical structure size|
|regulation of lymphocyte activation|
|cell population proliferation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|cell morphogenesis|
|cellular component morphogenesis|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|cell activation|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of developmental process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.71|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14844
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL7R Expression in NALM6 Cells: 9.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>