======= IL8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL8
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3576|3576]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10145|P10145]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-8 receptor binding|
|regulation of entry of bacterium into host cell|
|PERK-mediated unfolded protein response|
|induction of positive chemotaxis|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|positive regulation of neutrophil chemotaxis|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|positive regulation of granulocyte chemotaxis|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|embryonic digestive tract development|
|ER-nucleus signaling pathway|
|regulation of neutrophil migration|
|regulation of granulocyte chemotaxis|
|negative regulation of G protein-coupled receptor signaling pathway|
|chemokine activity|
|receptor internalization|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|regulation of viral genome replication|
|granulocyte migration|
|receptor metabolic process|
|endoplasmic reticulum unfolded protein response|
|cellular response to fibroblast growth factor stimulus|
|antimicrobial humoral response|
|regulation of leukocyte chemotaxis|
|response to fibroblast growth factor|
|cellular response to unfolded protein|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|digestive tract development|
|positive regulation of chemotaxis|
|digestive system development|
|regulation of G protein-coupled receptor signaling pathway|
|leukocyte chemotaxis|
|regulation of viral life cycle|
|cell cycle arrest|
|calcium-mediated signaling|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|positive regulation of angiogenesis|
|cellular response to interleukin-1|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|response to topologically incorrect protein|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|response to interleukin-1|
|regulation of viral process|
|cell chemotaxis|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|receptor-mediated endocytosis|
|cellular response to tumor necrosis factor|
|response to endoplasmic reticulum stress|
|response to tumor necrosis factor|
|regulation of angiogenesis|
|response to lipopolysaccharide|
|angiogenesis|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|second-messenger-mediated signaling|
|humoral immune response|
|leukocyte migration|
|blood vessel morphogenesis|
|embryonic organ development|
|blood vessel development|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|endocytosis|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|import into cell|
|regulation of cell adhesion|
|response to bacterium|
|regulation of multi-organism process|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|leukocyte activation|
|cell migration|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|cell cycle process|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.87|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.81|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17941
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL8 Expression in NALM6 Cells: -2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>