======= ILF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ILF3
  * **<color #00a2e8>Official Name</color>**: interleukin enhancer binding factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3609|3609]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12906|Q12906]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ILF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ILF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603182|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsrm|
|DZF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA 3-UTR AU-rich region binding|
|single-stranded RNA binding|
|negative regulation of viral genome replication|
|double-stranded RNA binding|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|negative regulation of translation|
|regulation of viral life cycle|
|negative regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|defense response to virus|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|response to virus|
|regulation of translation|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|regulation of multi-organism process|
|nucleolus|
|defense response to other organism|
|protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|immune effector process|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.22|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.97|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.69|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.52|
|[[:results:exp539|42°C R08 exp539]]|-2.38|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.31|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.22|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.18|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.08|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.07|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.05|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.05|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.99|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.97|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.94|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.89|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.89|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.84|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.82|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.82|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.79|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.73|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.71|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.73|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.85|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.86|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.98|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.22|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.32|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 575/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|20/28|
|bone|20/26|
|breast|20/33|
|central nervous system|46/56|
|cervix|4/4|
|colorectal|10/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|16/21|
|liver|15/20|
|lung|58/75|
|lymphocyte|15/16|
|ovary|22/26|
|pancreas|21/24|
|peripheral nervous system|11/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ILF3 Expression in NALM6 Cells: 10.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>