======= ILK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ILK
  * **<color #00a2e8>Official Name</color>**: integrin linked kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3611|3611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13418|Q13418]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ILK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ILK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor-proximal protein kinase regulating integrin- mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage- dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). {ECO:0000269|PubMed:8538749, ECO:0000269|PubMed:9736715, ECO:0000303|PubMed:10712922}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Ank|
|Ank 2|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibroblast migration|
|myelin assembly|
|costamere|
|negative regulation of cardiac muscle cell apoptotic process|
|positive regulation of myoblast differentiation|
|negative regulation of smooth muscle cell migration|
|negative regulation of neural precursor cell proliferation|
|negative regulation of striated muscle cell apoptotic process|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|Schwann cell development|
|positive regulation of BMP signaling pathway|
|Schwann cell differentiation|
|dendritic shaft|
|negative regulation of muscle cell apoptotic process|
|regulation of cardiac muscle cell apoptotic process|
|protein kinase B signaling|
|positive regulation of dendrite morphogenesis|
|regulation of striated muscle cell apoptotic process|
|positive regulation of axon extension|
|platelet aggregation|
|branching involved in ureteric bud morphogenesis|
|negative regulation of smooth muscle cell proliferation|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|terminal bouton|
|sarcomere|
|positive regulation of cell-matrix adhesion|
|substrate adhesion-dependent cell spreading|
|regulation of myoblast differentiation|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|positive regulation of osteoblast differentiation|
|homotypic cell-cell adhesion|
|regulation of smooth muscle cell migration|
|nephron tubule morphogenesis|
|cell aging|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|regulation of muscle cell apoptotic process|
|renal tubule morphogenesis|
|stress fiber|
|outflow tract morphogenesis|
|positive regulation of dendrite development|
|peripheral nervous system development|
|nephron tubule development|
|positive regulation of NIK/NF-kappaB signaling|
|nerve development|
|renal tubule development|
|kidney morphogenesis|
|positive regulation of ossification|
|positive regulation of axonogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of BMP signaling pathway|
|regulation of neural precursor cell proliferation|
|mesonephros development|
|regulation of dendrite morphogenesis|
|integrin-mediated signaling pathway|
|nephron epithelium development|
|regulation of axon extension|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular component assembly involved in morphogenesis|
|myelination|
|glial cell development|
|protein heterooligomerization|
|axon ensheathment|
|ensheathment of neurons|
|regulation of NIK/NF-kappaB signaling|
|regulation of extent of cell growth|
|regulation of osteoblast differentiation|
|regulation of cell-matrix adhesion|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of cell-substrate adhesion|
|nephron development|
|cell-matrix adhesion|
|kidney epithelium development|
|SH3 domain binding|
|branching morphogenesis of an epithelial tube|
|integrin binding|
|regulation of smooth muscle cell proliferation|
|platelet activation|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of neuron apoptotic process|
|cell cycle arrest|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|morphogenesis of a branching epithelium|
|positive regulation of cell growth|
|positive regulation of protein kinase B signaling|
|cell junction assembly|
|morphogenesis of a branching structure|
|glial cell differentiation|
|positive regulation of developmental growth|
|cell-cell junction|
|ameboidal-type cell migration|
|peptidyl-serine phosphorylation|
|positive regulation of Wnt signaling pathway|
|lamellipodium|
|regulation of cell size|
|cell-substrate adhesion|
|regulation of axonogenesis|
|regulation of ossification|
|establishment or maintenance of cell polarity|
|peptidyl-serine modification|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of cell-substrate adhesion|
|gliogenesis|
|cell junction organization|
|regulation of protein kinase B signaling|
|negative regulation of protein kinase activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to tumor necrosis factor|
|negative regulation of kinase activity|
|heart morphogenesis|
|positive regulation of growth|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|aging|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|urogenital system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|positive regulation of neuron differentiation|
|neuronal cell body|
|MAPK cascade|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|focal adhesion|
|regulation of cell growth|
|morphogenesis of an epithelium|
|negative regulation of phosphorylation|
|supramolecular fiber organization|
|protein kinase binding|
|positive regulation of neurogenesis|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of body fluid levels|
|positive regulation of cell migration|
|cell-cell adhesion|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of cell motility|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cell junction|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|protein-containing complex|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|cell cycle process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8465
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ILK Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>