======= IMPACT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IMPACT
  * **<color #00a2e8>Official Name</color>**: impact RWD domain protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55364|55364]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2X3|Q9P2X3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IMPACT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IMPACT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615319|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1- mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. {ECO:0000250|UniProtKB:O55091}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RWD|
|UPF0029|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to benomyl|
|cellular response to benomyl|
|regulation of eIF2 alpha phosphorylation by amino acid starvation|
|positive regulation of translational initiation in response to starvation|
|regulation of translational initiation in response to starvation|
|positive regulation of translational initiation in response to stress|
|positive regulation of translation in response to stress|
|cellular response to UV-C|
|cellular response to leucine starvation|
|regulation of translational initiation in response to stress|
|response to fungicide|
|cellular response to acidic pH|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|negative regulation of protein autophosphorylation|
|response to UV-C|
|regulation of translation in response to stress|
|response to acidic pH|
|cellular response to pH|
|positive regulation of translational initiation|
|response to pH|
|cellular response to glucose starvation|
|cellular response to amino acid starvation|
|polysome|
|response to amino acid starvation|
|regulation of protein autophosphorylation|
|ribosome binding|
|neuron projection extension|
|cellular response to hydrogen peroxide|
|regulation of translational initiation|
|cellular response to UV|
|developmental cell growth|
|cell growth|
|cellular response to light stimulus|
|developmental growth involved in morphogenesis|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|positive regulation of translation|
|regulation of DNA-templated transcription in response to stress|
|negative regulation of protein complex assembly|
|cellular response to reactive oxygen species|
|response to UV|
|positive regulation of cellular amide metabolic process|
|cellular response to starvation|
|cellular response to radiation|
|response to starvation|
|response to reactive oxygen species|
|cellular response to toxic substance|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|cellular response to extracellular stimulus|
|actin binding|
|response to antibiotic|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|cellular response to external stimulus|
|regulation of translation|
|positive regulation of neuron differentiation|
|response to oxidative stress|
|developmental growth|
|growth|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|response to radiation|
|negative regulation of phosphorylation|
|cellular component|
|regulation of protein complex assembly|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|response to nutrient levels|
|response to toxic substance|
|cell part morphogenesis|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|negative regulation of cellular component organization|
|cell morphogenesis|
|regulation of cellular response to stress|
|molecular function|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|negative regulation of transcription by RNA polymerase II|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14244
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IMPACT Expression in NALM6 Cells: 1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>