======= IMPDH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IMPDH2
  * **<color #00a2e8>Official Name</color>**: inosine monophosphate dehydrogenase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3615|3615]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12268|P12268]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IMPDH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IMPDH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NMO|
|CBS|
|IMPDH|
|FMN dh|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IMP dehydrogenase activity|
|GMP biosynthetic process|
|GTP biosynthetic process|
|guanosine-containing compound biosynthetic process|
|GMP metabolic process|
|purine ribonucleoside monophosphate biosynthetic process|
|purine nucleoside monophosphate biosynthetic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|purine nucleoside biosynthetic process|
|GTP metabolic process|
|cellular response to interleukin-4|
|response to interleukin-4|
|ribonucleoside monophosphate biosynthetic process|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|nucleoside biosynthetic process|
|guanosine-containing compound metabolic process|
|glycosyl compound biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|peroxisomal membrane|
|purine ribonucleoside triphosphate metabolic process|
|purine ribonucleoside metabolic process|
|nucleotide binding|
|nucleoside triphosphate biosynthetic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|protein homotetramerization|
|nucleoside triphosphate metabolic process|
|leukocyte proliferation|
|nucleobase-containing small molecule biosynthetic process|
|nucleoside metabolic process|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|glycosyl compound metabolic process|
|retina development in camera-type eye|
|circadian rhythm|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|rhythmic process|
|purine ribonucleotide metabolic process|
|camera-type eye development|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|eye development|
|visual system development|
|sensory system development|
|purine-containing compound metabolic process|
|lymphocyte activation|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|sensory organ development|
|cell population proliferation|
|myeloid leukocyte activation|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|secretion by cell|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.72|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.73|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.78|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.83|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.97|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.24|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.28|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.35|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.37|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.43|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.49|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.66|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.77|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.81|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.92|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.97|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|3.25|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|5.25|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|5.59|
|[[:results:exp116|AICAR 240μM R03 exp116]]|5.89|
|[[:results:exp211|AICAR 240μM R05 exp211]]|7.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bptf|BPTF]]|0.427|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 82/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|0/26|
|breast|4/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|4/21|
|liver|2/20|
|lung|11/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|9/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 272
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IMPDH2 Expression in NALM6 Cells: 7.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>