======= INPP5K =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INPP5K
  * **<color #00a2e8>Official Name</color>**: inositol polyphosphate-5-phosphatase K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51763|51763]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT40|Q9BT40]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INPP5K&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INPP5K|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607875|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CALCOCO1|
|Exo endo phos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of renal water transport|
|phosphatidylinositol trisphosphate phosphatase activity|
|regulation of renal water transport|
|inositol trisphosphate phosphatase activity|
|inositol bisphosphate phosphatase activity|
|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|
|negative regulation of glycogen (starch) synthase activity|
|phosphatidylinositol phosphate 5-phosphatase activity|
|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|
|inositol-1,4,5-trisphosphate 5-phosphatase activity|
|inositol-polyphosphate 5-phosphatase activity|
|negative regulation of glycogen biosynthetic process|
|negative regulation of protein targeting to membrane|
|vasopressin receptor activity|
|negative regulation of glycogen metabolic process|
|regulation of glycogen (starch) synthase activity|
|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|
|lipid phosphatase activity|
|ruffle assembly|
|positive regulation of urine volume|
|inositol phosphate dephosphorylation|
|negative regulation by host of viral transcription|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|phosphorylated carbohydrate dephosphorylation|
|inositol phosphate catabolic process|
|negative regulation of glucose transmembrane transport|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|negative regulation of peptidyl-threonine phosphorylation|
|negative regulation of stress fiber assembly|
|regulation of urine volume|
|phosphatidylinositol dephosphorylation|
|negative regulation of actin filament bundle assembly|
|ruffle organization|
|polyol catabolic process|
|negative regulation of viral transcription|
|negative regulation of peptidyl-serine phosphorylation|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|negative regulation of protein localization to membrane|
|phospholipid dephosphorylation|
|negative regulation of insulin receptor signaling pathway|
|regulation of glycogen metabolic process|
|regulation of renal system process|
|negative regulation of cellular response to insulin stimulus|
|regulation of protein targeting to membrane|
|regulation of polysaccharide biosynthetic process|
|negative regulation of intracellular protein transport|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of polysaccharide metabolic process|
|cellular response to epidermal growth factor stimulus|
|regulation of peptidyl-threonine phosphorylation|
|negative regulation of protein kinase B signaling|
|response to epidermal growth factor|
|negative regulation of carbohydrate metabolic process|
|cellular response to cAMP|
|alcohol catabolic process|
|inositol phosphate metabolic process|
|negative regulation of viral genome replication|
|negative regulation of calcium ion transport|
|negative regulation of intracellular transport|
|regulation of viral transcription|
|regulation of insulin receptor signaling pathway|
|modification by host of symbiont morphology or physiology|
|regulation of cellular response to insulin stimulus|
|regulation of glucose transmembrane transport|
|negative regulation of MAP kinase activity|
|organic hydroxy compound catabolic process|
|interaction with symbiont|
|regulation of stress fiber assembly|
|negative regulation of viral life cycle|
|regulation of protein targeting|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|ruffle|
|regulation of viral genome replication|
|regulation of carbohydrate biosynthetic process|
|ruffle membrane|
|negative regulation of viral process|
|response to cAMP|
|phosphatidylinositol biosynthetic process|
|renal system process|
|polyol metabolic process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|negative regulation of dephosphorylation|
|negative regulation of cellular protein localization|
|regulation of glucose metabolic process|
|negative regulation of transmembrane transport|
|organophosphate catabolic process|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein serine/threonine kinase activity|
|response to organophosphorus|
|regulation of peptidyl-serine phosphorylation|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of cytoskeleton organization|
|regulation of viral life cycle|
|negative regulation of ion transport|
|response to purine-containing compound|
|modification of morphology or physiology of other organism|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|negative regulation of MAPK cascade|
|phosphatidylinositol metabolic process|
|trans-Golgi network|
|cellular carbohydrate metabolic process|
|negative regulation of protein transport|
|protein localization to plasma membrane|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|lipid modification|
|regulation of carbohydrate metabolic process|
|regulation of viral process|
|glycerophospholipid biosynthetic process|
|regulation of dephosphorylation|
|negative regulation of multi-organism process|
|regulation of protein kinase B signaling|
|regulation of symbiosis, encompassing mutualism through parasitism|
|glycerolipid biosynthetic process|
|negative regulation of protein kinase activity|
|response to insulin|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|cellular response to tumor necrosis factor|
|negative regulation of kinase activity|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|regulation of actin filament organization|
|response to tumor necrosis factor|
|cellular response to peptide hormone stimulus|
|negative regulation of transferase activity|
|glycerophospholipid metabolic process|
|dephosphorylation|
|alcohol metabolic process|
|neuron projection|
|cellular response to peptide|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|negative regulation of organelle organization|
|phospholipid metabolic process|
|in utero embryonic development|
|glycerolipid metabolic process|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|response to peptide hormone|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|small molecule catabolic process|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|organic hydroxy compound metabolic process|
|cell projection assembly|
|response to peptide|
|carbohydrate metabolic process|
|protein localization to membrane|
|negative regulation of transport|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|response to growth factor|
|organophosphate biosynthetic process|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|actin filament-based process|
|lipid biosynthetic process|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|cellular response to nitrogen compound|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|organophosphate metabolic process|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|embryo development|
|positive regulation of transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.77|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.87|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.82|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.76|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.77|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.81|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14383
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INPP5K Expression in NALM6 Cells: 4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>