======= INTS12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS12
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57117|57117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CB8|Q96CB8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTS12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTS12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611355|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|RNA 3-end processing|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-3.1|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.92|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.9|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.88|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.72|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.58|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-2.54|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.51|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.45|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.33|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.32|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.27|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.27|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.26|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.24|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.22|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.19|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.18|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.13|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.03|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.02|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.01|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.98|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.97|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.97|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.94|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.94|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.93|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.87|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.86|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.84|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.84|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.8|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.77|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.74|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.73|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.72|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.72|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.71|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.71|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.71|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.75|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.76|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.09|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.66|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.74|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.75|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.94|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints8|INTS8]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/25|
|breast|4/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|3/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16462
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTS12 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>