======= IPO5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPO5
  * **<color #00a2e8>Official Name</color>**: importin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3843|3843]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00410|O00410]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPO5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPO5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602008|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000250|UniProtKB:Q8BKC5, ECO:0000269|PubMed:9687515}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vac14 Fab1 bd|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal protein import into nucleus|
|GTPase inhibitor activity|
|NLS-bearing protein import into nucleus|
|nuclear import signal receptor activity|
|nuclear localization sequence binding|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|Ran GTPase binding|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|negative regulation of GTPase activity|
|regulation of protein import into nucleus|
|regulation of protein import|
|positive regulation of nucleocytoplasmic transport|
|cellular response to amino acid stimulus|
|nuclear pore|
|positive regulation of protein localization to nucleus|
|protein import into nucleus|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|regulation of nucleocytoplasmic transport|
|response to amino acid|
|import into nucleus|
|regulation of protein localization to nucleus|
|negative regulation of protein serine/threonine kinase activity|
|protein import|
|positive regulation of intracellular protein transport|
|protein localization to nucleus|
|positive regulation of intracellular transport|
|cellular response to acid chemical|
|negative regulation of protein kinase activity|
|regulation of intracellular protein transport|
|negative regulation of kinase activity|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of transferase activity|
|positive regulation of cellular protein localization|
|response to acid chemical|
|regulation of intracellular transport|
|negative regulation of protein phosphorylation|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|regulation of GTPase activity|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|viral process|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|nucleolus|
|regulation of kinase activity|
|regulation of cellular localization|
|regulation of transferase activity|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|RNA binding|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.14|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.7|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.73|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.89|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.2|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.23|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.3|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.3|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.44|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPO5 Expression in NALM6 Cells: 8.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>