======= IPO7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IPO7
  * **<color #00a2e8>Official Name</color>**: importin 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10527|10527]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95373|O95373]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IPO7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IPO7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605586|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates the nuclear import of HIV-1 reverse transcription complex (RTC) integrase. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:9687515}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cse1|
|IBN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTPase regulator activity|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|Ran GTPase binding|
|transporter activity|
|SMAD binding|
|nuclear pore|
|protein import into nucleus|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|import into nucleus|
|histone binding|
|negative regulation of protein serine/threonine kinase activity|
|protein import|
|protein localization to nucleus|
|nuclear envelope|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of transferase activity|
|negative regulation of protein phosphorylation|
|establishment of protein localization to organelle|
|negative regulation of phosphorylation|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|viral process|
|protein localization to organelle|
|innate immune response|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|defense response to other organism|
|regulation of transferase activity|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 503/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|18/28|
|blood|15/28|
|bone|15/26|
|breast|23/33|
|central nervous system|38/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|14/21|
|liver|15/20|
|lung|54/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|13/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|15/22|
|urinary tract|22/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IPO7 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>