======= IRF2BP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRF2BP2
  * **<color #00a2e8>Official Name</color>**: interferon regulatory factor 2 binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=359948|359948]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5L9|Q7Z5L9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRF2BP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRF2BP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615332|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. {ECO:0000269|PubMed:12799427, ECO:0000269|PubMed:20702774, ECO:0000269|PubMed:21576369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF-2BP1 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immature B cell differentiation|
|B cell differentiation|
|B cell activation|
|lymphocyte differentiation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|leukocyte differentiation|
|lymphocyte activation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|leukocyte activation|
|cell activation|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.19|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.18|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.86|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.86|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.83|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.7|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.75|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.79|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.82|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.84|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.95|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.19|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.47|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nsd1|NSD1]]|0.552|
|[[:human genes:x:xpo6|XPO6]]|0.544|
|[[:human genes:i:id3|ID3]]|0.539|
|[[:human genes:d:dnajc3|DNAJC3]]|0.528|
|[[:human genes:m:maml1|MAML1]]|0.507|
|[[:human genes:t:trim28|TRIM28]]|0.504|
|[[:human genes:m:manf|MANF]]|0.497|
|[[:human genes:a:asxl2|ASXL2]]|0.495|
|[[:human genes:s:sec62|SEC62]]|0.488|
|[[:human genes:c:ccdc101|CCDC101]]|0.484|
|[[:human genes:m:mef2c|MEF2C]]|0.481|
|[[:human genes:a:alg5|ALG5]]|0.472|
|[[:human genes:s:sec63|SEC63]]|0.471|
|[[:human genes:z:zfx|ZFX]]|0.469|
|[[:human genes:s:ssbp2|SSBP2]]|0.467|
|[[:human genes:p:pmm2|PMM2]]|0.461|
|[[:human genes:c:cbfb|CBFB]]|0.46|
|[[:human genes:d:dohh|DOHH]]|0.457|
|[[:human genes:d:dpagt1|DPAGT1]]|0.457|
|[[:human genes:s:sox7|SOX7]]|0.455|
|[[:human genes:t:trmt10a|TRMT10A]]|0.455|
|[[:human genes:u:ube2g2|UBE2G2]]|0.452|
|[[:human genes:t:taf5l|TAF5L]]|0.448|
|[[:human genes:a:alg9|ALG9]]|0.448|
|[[:human genes:p:pdap1|PDAP1]]|0.444|
|[[:human genes:r:rnmt|RNMT]]|0.444|
|[[:human genes:d:ddx5|DDX5]]|0.443|
|[[:human genes:b:bap1|BAP1]]|0.442|
|[[:human genes:o:opa1|OPA1]]|0.439|
|[[:human genes:u:ube2j1|UBE2J1]]|0.437|
|[[:human genes:m:med25|MED25]]|0.437|
|[[:human genes:d:dhrsx|DHRSX]]|0.436|
|[[:human genes:t:taz|TAZ]]|0.435|
|[[:human genes:u:ube2l3|UBE2L3]]|0.433|
|[[:human genes:s:scaf8|SCAF8]]|0.432|
|[[:human genes:f:fli1|FLI1]]|0.432|
|[[:human genes:m:mbtps2|MBTPS2]]|0.431|
|[[:human genes:e:erg|ERG]]|0.431|
|[[:human genes:t:tceb3|TCEB3]]|0.428|
|[[:human genes:s:slc35b1|SLC35B1]]|0.428|
|[[:human genes:u:usp22|USP22]]|0.426|
|[[:human genes:r:rptor|RPTOR]]|0.424|
|[[:human genes:b:brpf1|BRPF1]]|0.423|
|[[:human genes:x:xpot|XPOT]]|0.421|
|[[:human genes:u:uap1|UAP1]]|0.415|
|[[:human genes:t:thg1l|THG1L]]|0.414|
|[[:human genes:t:triap1|TRIAP1]]|0.414|
|[[:human genes:a:atf7ip|ATF7IP]]|0.413|
|[[:human genes:m:med16|MED16]]|0.413|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.413|
|[[:human genes:e:eef1e1|EEF1E1]]|0.411|
|[[:human genes:d:dcaf5|DCAF5]]|0.409|
|[[:human genes:r:romo1|ROMO1]]|0.407|
|[[:human genes:h:hhex|HHEX]]|0.406|
|[[:human genes:m:mlst8|MLST8]]|0.406|
|[[:human genes:e:eif1|EIF1]]|0.405|
|[[:human genes:a:alg3|ALG3]]|0.404|
|[[:human genes:r:runx1|RUNX1]]|0.403|
|[[:human genes:z:znf592|ZNF592]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRF2BP2 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>