======= IRF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRF7
  * **<color #00a2e8>Official Name</color>**: interferon regulatory factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3665|3665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92985|Q92985]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605047|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. {ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802, ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF|
|IRF-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type I interferon biosynthetic process|
|MDA-5 signaling pathway|
|interferon-alpha production|
|interferon-beta production|
|regulation of MyD88-dependent toll-like receptor signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway in response to virus|
|negative regulation of macrophage apoptotic process|
|regulation of MyD88-independent toll-like receptor signaling pathway|
|type I interferon production|
|establishment of viral latency|
|regulation of macrophage apoptotic process|
|viral latency|
|positive regulation of type I interferon-mediated signaling pathway|
|cytokine biosynthetic process|
|cytokine metabolic process|
|negative regulation of myeloid cell apoptotic process|
|regulation of monocyte differentiation|
|multi-organism cellular process|
|positive regulation of interferon-alpha production|
|enhancer sequence-specific DNA binding|
|TRIF-dependent toll-like receptor signaling pathway|
|regulation of myeloid cell apoptotic process|
|regulation of interferon-alpha production|
|positive regulation of interferon-beta production|
|cellular response to virus|
|MyD88-independent toll-like receptor signaling pathway|
|regulation of type I interferon-mediated signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of leukocyte apoptotic process|
|regulation of interferon-beta production|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of response to cytokine stimulus|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|regulation of toll-like receptor signaling pathway|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|positive regulation of type I interferon production|
|regulation of leukocyte apoptotic process|
|toll-like receptor signaling pathway|
|regulation of myeloid leukocyte differentiation|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|cytokine production|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|intracellular receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|response to interferon-gamma|
|defense response to virus|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|endosome membrane|
|regulation of myeloid cell differentiation|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|lymphocyte mediated immunity|
|regulation of leukocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of defense response|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|adaptive immune response|
|activation of immune response|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cytokine-mediated signaling pathway|
|regulation of cytokine production|
|viral process|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|defense response to other organism|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.79|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.86|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRF7 Expression in NALM6 Cells: 3.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>