======= IRX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRX3
  * **<color #00a2e8>Official Name</color>**: iroquois homeobox 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79191|79191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78415|P78415]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612985|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|Homeobox KN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|specification of loop of Henle identity|
|specification of nephron tubule identity|
|proximal/distal pattern formation involved in nephron development|
|pattern specification involved in kidney development|
|renal system pattern specification|
|loop of Henle development|
|segment specification|
|nephron tubule formation|
|proximal/distal pattern formation|
|energy homeostasis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|kidney morphogenesis|
|segmentation|
|nephron epithelium development|
|embryonic epithelial tube formation|
|nephron development|
|mesoderm development|
|kidney epithelium development|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|negative regulation of neuron differentiation|
|kidney development|
|renal system development|
|negative regulation of neurogenesis|
|axon|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|urogenital system development|
|multicellular organismal homeostasis|
|regionalization|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|pattern specification process|
|positive regulation of neurogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|regulation of neuron differentiation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|epithelium development|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|homeostatic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.07|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.53|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16953
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRX3 Expression in NALM6 Cells: 1.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>