======= IRX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRX5
  * **<color #00a2e8>Official Name</color>**: iroquois homeobox 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10265|10265]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78411|P78411]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606195|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. {ECO:0000250, ECO:0000269|PubMed:22581230}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox KN|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal bipolar neuron differentiation|
|vitamin D binding|
|neuron maturation|
|embryonic cranial skeleton morphogenesis|
|retina morphogenesis in camera-type eye|
|neural retina development|
|cranial skeletal system development|
|embryonic skeletal system morphogenesis|
|regulation of heart rate|
|camera-type eye morphogenesis|
|embryonic skeletal system development|
|anatomical structure maturation|
|retina development in camera-type eye|
|eye morphogenesis|
|cell maturation|
|gonad development|
|development of primary sexual characteristics|
|visual perception|
|sensory perception of light stimulus|
|skeletal system morphogenesis|
|developmental maturation|
|regulation of heart contraction|
|sensory organ morphogenesis|
|sex differentiation|
|regulation of blood circulation|
|embryonic organ morphogenesis|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|skeletal system development|
|sensory organ development|
|embryonic morphogenesis|
|regulation of system process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|neuron development|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|neuron differentiation|
|nervous system process|
|reproductive process|
|reproduction|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.98|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRX5 Expression in NALM6 Cells: 1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>