======= ISL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ISL1
  * **<color #00a2e8>Official Name</color>**: ISL LIM homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3670|3670]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61371|P61371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ISL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ISL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600366|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). {ECO:0000250|UniProtKB:P61372, ECO:0000250|UniProtKB:P61374}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peripheral nervous system neuron axonogenesis|
|visceral motor neuron differentiation|
|positive regulation of macrophage colony-stimulating factor production|
|positive regulation of granulocyte colony-stimulating factor production|
|cardiac cell fate determination|
|negative regulation of protein homodimerization activity|
|positive regulation of interleukin-1 alpha production|
|regulation of granulocyte colony-stimulating factor production|
|regulation of macrophage colony-stimulating factor production|
|regulation of interleukin-1 alpha production|
|secondary heart field specification|
|regulation of secondary heart field cardioblast proliferation|
|heart field specification|
|cardiac cell fate commitment|
|regulation of cardioblast proliferation|
|cardiac muscle cell myoblast differentiation|
|trigeminal nerve development|
|peripheral nervous system neuron differentiation|
|peripheral nervous system neuron development|
|cardioblast differentiation|
|heart formation|
|spinal cord motor neuron cell fate specification|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|negative regulation of intracellular estrogen receptor signaling pathway|
|regulation of granulocyte macrophage colony-stimulating factor production|
|specification of animal organ identity|
|atrial septum morphogenesis|
|regulation of cell proliferation involved in heart morphogenesis|
|retinal ganglion cell axon guidance|
|cardiac right ventricle morphogenesis|
|nuclear receptor binding|
|atrial septum development|
|regulation of protein homodimerization activity|
|axon regeneration|
|enhancer sequence-specific DNA binding|
|bHLH transcription factor binding|
|pharyngeal system development|
|innervation|
|positive regulation of vascular endothelial growth factor production|
|outflow tract septum morphogenesis|
|neuron projection regeneration|
|cardiac atrium morphogenesis|
|positive regulation of histone acetylation|
|regulation of vascular endothelial growth factor production|
|positive regulation of peptidyl-lysine acetylation|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|animal organ formation|
|myoblast differentiation|
|cardiac atrium development|
|endocardial cushion morphogenesis|
|positive regulation of interleukin-12 production|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of animal organ formation|
|cell fate determination|
|regulation of heart morphogenesis|
|regulation of intracellular estrogen receptor signaling pathway|
|positive regulation of protein acetylation|
|pituitary gland development|
|endocardial cushion development|
|estrogen receptor binding|
|positive regulation of epithelial to mesenchymal transition|
|ventral spinal cord development|
|ventricular cardiac muscle tissue morphogenesis|
|promoter-specific chromatin binding|
|response to axon injury|
|mesenchyme morphogenesis|
|cranial nerve development|
|positive regulation of interleukin-1 beta production|
|RNA polymerase II activating transcription factor binding|
|cell differentiation in spinal cord|
|regulation of interleukin-12 production|
|neural crest cell migration|
|ventricular cardiac muscle tissue development|
|cellular response to glucocorticoid stimulus|
|positive regulation of DNA binding|
|regulation of histone acetylation|
|positive regulation of interleukin-1 production|
|cellular response to corticosteroid stimulus|
|regulation of peptidyl-lysine acetylation|
|neuron fate commitment|
|positive regulation of interferon-gamma production|
|cardiac muscle tissue morphogenesis|
|positive regulation of tyrosine phosphorylation of STAT protein|
|regulation of protein acetylation|
|pancreas development|
|positive regulation of insulin secretion|
|cardiac ventricle morphogenesis|
|peripheral nervous system development|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|diencephalon development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|nerve development|
|regulation of tyrosine phosphorylation of STAT protein|
|neural crest cell development|
|muscle tissue morphogenesis|
|regulation of interleukin-1 beta production|
|stem cell development|
|regulation of epithelial to mesenchymal transition|
|mesenchymal cell development|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of tumor necrosis factor production|
|muscle organ morphogenesis|
|cell fate specification|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of receptor signaling pathway via STAT|
|neural crest cell differentiation|
|positive regulation of histone modification|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|positive regulation of peptide hormone secretion|
|regulation of interferon-gamma production|
|negative regulation of protein binding|
|positive regulation of chromatin organization|
|spinal cord development|
|cardiac septum development|
|cardiocyte differentiation|
|endocrine system development|
|negative regulation of epithelial cell proliferation|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|positive regulation of hormone secretion|
|cardiac ventricle development|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|negative regulation of inflammatory response|
|regulation of interleukin-6 production|
|response to glucocorticoid|
|negative regulation of neuron apoptotic process|
|regulation of histone modification|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regeneration|
|mesenchymal cell differentiation|
|stem cell differentiation|
|response to corticosteroid|
|cardiac muscle tissue development|
|positive regulation of angiogenesis|
|negative regulation of binding|
|cardiac chamber development|
|ameboidal-type cell migration|
|positive regulation of chromosome organization|
|negative regulation of canonical Wnt signaling pathway|
|regulation of insulin secretion|
|positive regulation of binding|
|central nervous system neuron differentiation|
|positive regulation of vasculature development|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|negative regulation of defense response|
|negative regulation of Wnt signaling pathway|
|regulation of peptide hormone secretion|
|regulation of protein binding|
|mesenchyme development|
|negative regulation of neuron differentiation|
|cell fate commitment|
|heart morphogenesis|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of animal organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of canonical Wnt signaling pathway|
|transcription coactivator activity|
|striated muscle tissue development|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|muscle organ development|
|muscle tissue development|
|regulation of neuron death|
|negative regulation of nervous system development|
|regulation of vasculature development|
|response to steroid hormone|
|regionalization|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|regulation of chromosome organization|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|sensory system development|
|axonogenesis|
|regulation of binding|
|forebrain development|
|positive regulation of secretion by cell|
|axon development|
|gland development|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|muscle structure development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|cellular response to lipid|
|heart development|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|response to wounding|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|neuron projection development|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|head development|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.72|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|4/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4294
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ISL1 Expression in NALM6 Cells: -2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>