======= ITGA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGA5
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3678|3678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08648|P08648]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/135620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:25398877}. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. {ECO:0000269|PubMed:24478423}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin alpha2|
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alphav-beta3 integrin-vitronectin complex|
|cell-cell adhesion mediated by integrin|
|vascular endothelial growth factor receptor 2 binding|
|wound healing, spreading of epidermal cells|
|platelet-derived growth factor receptor binding|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|negative regulation of anoikis|
|cell adhesion mediated by integrin|
|regulation of anoikis|
|epiboly involved in wound healing|
|wound healing, spreading of cells|
|integrin complex|
|epiboly|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|epidermal growth factor receptor binding|
|heterotypic cell-cell adhesion|
|positive regulation of sprouting angiogenesis|
|endodermal cell differentiation|
|cell-substrate junction assembly|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|endoderm formation|
|morphogenesis of an epithelial sheet|
|leukocyte cell-cell adhesion|
|regulation of sprouting angiogenesis|
|endoderm development|
|virus receptor activity|
|ruffle|
|integrin-mediated signaling pathway|
|viral entry into host cell|
|ruffle membrane|
|entry into host cell|
|entry into host|
|formation of primary germ layer|
|memory|
|positive regulation of cell-substrate adhesion|
|integrin binding|
|interaction with host|
|gastrulation|
|positive regulation of angiogenesis|
|cell junction assembly|
|cell-cell junction|
|female pregnancy|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|positive regulation of peptidyl-tyrosine phosphorylation|
|viral life cycle|
|multi-multicellular organism process|
|regulation of cell-substrate adhesion|
|cell junction organization|
|regulation of peptidyl-tyrosine phosphorylation|
|cytoplasmic vesicle|
|learning or memory|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|synapse|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|cognition|
|angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|leukocyte migration|
|extracellular structure organization|
|external side of plasma membrane|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|focal adhesion|
|morphogenesis of an epithelium|
|wound healing|
|blood vessel development|
|positive regulation of cell migration|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|behavior|
|cell surface|
|tube morphogenesis|
|regulation of cell adhesion|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|regulation of locomotion|
|Golgi apparatus|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.07|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGA5 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>