======= ITGB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB1
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3688|3688]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05556|P05556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/135630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin B tail|
|Integrin b cyt|
|Integrin beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alpha7-beta1 complex|
|integrin alpha3-beta1 complex|
|integrin alpha1-beta1 complex|
|integrin alpha11-beta1 complex|
|integrin alpha10-beta1 complex|
|integrin alpha8-beta1 complex|
|integrin alpha2-beta1 complex|
|formation of radial glial scaffolds|
|calcium-independent cell-matrix adhesion|
|regulation of collagen catabolic process|
|collagen binding involved in cell-matrix adhesion|
|C-X3-C chemokine binding|
|cell-cell adhesion mediated by integrin|
|integral component of synaptic membrane|
|invadopodium membrane|
|myelin sheath abaxonal region|
|germ cell migration|
|hindbrain radial glia guided cell migration|
|glial cell projection|
|cell migration in hindbrain|
|negative regulation of anoikis|
|stress fiber assembly|
|contractile actin filament bundle assembly|
|cellular response to low-density lipoprotein particle stimulus|
|leukocyte tethering or rolling|
|leukocyte adhesion to vascular endothelial cell|
|cell migration involved in sprouting angiogenesis|
|negative regulation of Rho protein signal transduction|
|basement membrane organization|
|cell adhesion mediated by integrin|
|laminin binding|
|regulation of anoikis|
|integrin complex|
|mesodermal cell differentiation|
|fibronectin binding|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|blood vessel endothelial cell migration|
|positive regulation of signaling receptor activity|
|lamellipodium assembly|
|coreceptor activity|
|axon extension|
|heterotypic cell-cell adhesion|
|cellular extravasation|
|regulation of collagen metabolic process|
|lamellipodium organization|
|intercalated disc|
|sarcomere organization|
|visual learning|
|leukocyte cell-cell adhesion|
|negative regulation of Ras protein signal transduction|
|cellular defense response|
|visual behavior|
|cleavage furrow|
|positive regulation of protein localization to plasma membrane|
|sprouting angiogenesis|
|cell adhesion molecule binding|
|dendrite morphogenesis|
|negative regulation of small GTPase mediated signal transduction|
|neuron projection extension|
|positive regulation of protein localization to cell periphery|
|receptor internalization|
|actin filament bundle assembly|
|endothelial cell migration|
|actin filament bundle organization|
|myofibril assembly|
|mesoderm formation|
|mesoderm morphogenesis|
|filopodium|
|virus receptor activity|
|neuromuscular junction|
|associative learning|
|Schaffer collateral - CA1 synapse|
|epithelial cell migration|
|epithelium migration|
|cell fate specification|
|developmental cell growth|
|cardiac muscle cell differentiation|
|cell growth|
|ruffle|
|tissue migration|
|integrin-mediated signaling pathway|
|regulation of protein localization to plasma membrane|
|viral entry into host cell|
|ruffle membrane|
|sarcolemma|
|melanosome|
|entry into host|
|transforming growth factor beta receptor signaling pathway|
|dendrite development|
|entry into host cell|
|protease binding|
|cellular component assembly involved in morphogenesis|
|receptor metabolic process|
|B cell differentiation|
|formation of primary germ layer|
|regulation of protein localization to cell periphery|
|actomyosin structure organization|
|developmental growth involved in morphogenesis|
|cardiocyte differentiation|
|recycling endosome|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|positive regulation of protein localization to membrane|
|mesoderm development|
|cell-matrix adhesion|
|integrin binding|
|striated muscle cell development|
|regulation of Rho protein signal transduction|
|learning|
|dendritic spine|
|muscle cell development|
|hindbrain development|
|B cell activation|
|cellular response to transforming growth factor beta stimulus|
|interaction with host|
|gastrulation|
|cardiac muscle tissue development|
|response to transforming growth factor beta|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|ameboidal-type cell migration|
|regulation of signaling receptor activity|
|lamellipodium|
|positive regulation of vasculature development|
|cell-substrate adhesion|
|regulation of protein localization to membrane|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|viral life cycle|
|striated muscle cell differentiation|
|receptor complex|
|regulation of protein kinase B signaling|
|membrane raft|
|receptor-mediated endocytosis|
|lymphocyte differentiation|
|actin filament organization|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|cell fate commitment|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|learning or memory|
|protein-containing complex binding|
|actin binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|striated muscle tissue development|
|regulation of angiogenesis|
|muscle tissue development|
|cognition|
|response to light stimulus|
|cadherin binding|
|angiogenesis|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|phagocytosis|
|leukocyte differentiation|
|extracellular matrix organization|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|cellular process involved in reproduction in multicellular organism|
|axonogenesis|
|in utero embryonic development|
|leukocyte migration|
|lymphocyte activation|
|extracellular structure organization|
|developmental growth|
|growth|
|external side of plasma membrane|
|blood vessel morphogenesis|
|axon development|
|positive regulation of GTPase activity|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|supramolecular fiber organization|
|cell projection assembly|
|muscle structure development|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|protein heterodimerization activity|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|cell-cell adhesion|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|endocytosis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|behavior|
|protein-containing complex|
|mitotic cell cycle process|
|hematopoietic or lymphoid organ development|
|cell surface|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|cytokine-mediated signaling pathway|
|import into cell|
|mitotic cell cycle|
|gamete generation|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|viral process|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|organelle assembly|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|defense response|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.53|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.46|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.08|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14914
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB1 Expression in NALM6 Cells: 7.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>