======= ITGB1BP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB1BP1
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 1 binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9270|9270]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14713|O14713]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB1BP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB1BP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607153|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin- dependent manner. Involved in the regulation of beta-1 integrin- containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:11741838, ECO:0000269|PubMed:11807099, ECO:0000269|PubMed:11919189, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15703214, ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:20616313, ECO:0000269|PubMed:21768292, ECO:0000269|Ref.19}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ICAP-1 inte bdg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell adhesion involved in substrate-bound cell migration|
|negative regulation of protein targeting to membrane|
|negative regulation of fibroblast migration|
|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|integrin activation|
|GDP-dissociation inhibitor activity|
|negative regulation of substrate adhesion-dependent cell spreading|
|myoblast migration|
|regulation of integrin-mediated signaling pathway|
|negative regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of focal adhesion assembly|
|negative regulation of adherens junction organization|
|muscle cell migration|
|negative regulation of cell junction assembly|
|endothelial cell proliferation|
|negative regulation of sprouting angiogenesis|
|positive regulation of focal adhesion assembly|
|substrate-dependent cell migration|
|negative regulation of protein localization to membrane|
|regulation of fibroblast migration|
|positive regulation of protein targeting to membrane|
|positive regulation of adherens junction organization|
|activation of protein kinase B activity|
|negative regulation of blood vessel endothelial cell migration|
|positive regulation of cell junction assembly|
|regulation of protein targeting to membrane|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of cell-matrix adhesion|
|cell periphery|
|cellular response to vascular endothelial growth factor stimulus|
|negative regulation of intracellular protein transport|
|regulation of cell adhesion mediated by integrin|
|receptor clustering|
|negative regulation of endothelial cell migration|
|positive regulation of cell-matrix adhesion|
|positive regulation of stress fiber assembly|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of Notch signaling pathway|
|sprouting angiogenesis|
|negative regulation of intracellular transport|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|positive regulation of actin filament bundle assembly|
|negative regulation of cell-substrate adhesion|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of epithelial cell migration|
|regulation of adherens junction organization|
|regulation of sprouting angiogenesis|
|regulation of stress fiber assembly|
|regulation of protein targeting|
|localization within membrane|
|epithelial cell proliferation|
|positive regulation of cell division|
|regulation of cell junction assembly|
|regulation of actomyosin structure organization|
|regulation of blood vessel endothelial cell migration|
|ruffle|
|biomineral tissue development|
|regulation of actin filament bundle assembly|
|biomineralization|
|integrin-mediated signaling pathway|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of endothelial cell migration|
|negative regulation of protein binding|
|negative regulation of angiogenesis|
|regulation of Notch signaling pathway|
|negative regulation of blood vessel morphogenesis|
|cellular response to fibroblast growth factor stimulus|
|negative regulation of cellular protein localization|
|regulation of cell-matrix adhesion|
|response to fibroblast growth factor|
|negative regulation of vasculature development|
|positive regulation of cell-substrate adhesion|
|positive regulation of protein localization to membrane|
|Notch signaling pathway|
|cell-matrix adhesion|
|integrin binding|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|tube formation|
|positive regulation of intracellular protein transport|
|microtubule organizing center|
|regulation of endothelial cell migration|
|positive regulation of protein kinase B signaling|
|negative regulation of MAPK cascade|
|regulation of cell division|
|vascular process in circulatory system|
|negative regulation of binding|
|lamellipodium|
|negative regulation of protein transport|
|protein localization to plasma membrane|
|cell-substrate adhesion|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|positive regulation of supramolecular fiber organization|
|positive regulation of intracellular transport|
|regulation of cell-substrate adhesion|
|regulation of protein binding|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|negative regulation of protein kinase activity|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|negative regulation of kinase activity|
|negative regulation of cell migration|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|nuclear body|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|regulation of binding|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|positive regulation of cell adhesion|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|focal adhesion|
|positive regulation of protein transport|
|negative regulation of phosphorylation|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|protein localization to membrane|
|regulation of GTPase activity|
|negative regulation of transport|
|blood vessel development|
|regulation of cell morphogenesis|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of organelle organization|
|tube morphogenesis|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.74|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.75|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.86|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11210
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB1BP1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>