======= ITIH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITIH3
  * **<color #00a2e8>Official Name</color>**: inter-alpha-trypsin inhibitor heavy chain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3699|3699]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06033|Q06033]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITIH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITIH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VIT|
|ITI HC C|
|VWA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet dense granule lumen|
|hyaluronan metabolic process|
|endopeptidase inhibitor activity|
|serine-type endopeptidase inhibitor activity|
|mucopolysaccharide metabolic process|
|platelet degranulation|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulated exocytosis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|exocytosis|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|export from cell|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|small molecule metabolic process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.27|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.94|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.83|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.77|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.7|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.77|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.82|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.95|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.02|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9737
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITIH3 Expression in NALM6 Cells: -0.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>