======= ITPR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITPR3
  * **<color #00a2e8>Official Name</color>**: inositol 1,4,5-trisphosphate receptor type 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3710|3710]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14573|Q14573]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITPR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITPR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|Ins145 P3 rec|
|RIH assoc|
|RYDR ITPR|
|MIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|
|inositol hexakisphosphate binding|
|inositol 1,3,4,5 tetrakisphosphate binding|
|sensory perception of sweet taste|
|sensory perception of umami taste|
|platelet dense tubular network membrane|
|calcium-release channel activity|
|inositol 1,4,5 trisphosphate binding|
|inositol phosphate-mediated signaling|
|nuclear outer membrane|
|myelin sheath|
|sarcoplasmic reticulum|
|sensory perception of bitter taste|
|long-term synaptic potentiation|
|brush border|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|sensory perception of taste|
|calcium ion transmembrane import into cytosol|
|regulation of cardiac conduction|
|apical part of cell|
|calcium ion transport into cytosol|
|phosphatidylinositol binding|
|cytosolic calcium ion transport|
|secretory granule membrane|
|protein heterooligomerization|
|memory|
|regulation of sequestering of calcium ion|
|platelet activation|
|cytoplasmic vesicle membrane|
|response to calcium ion|
|positive regulation of synaptic transmission|
|regulation of insulin secretion|
|regulation of synaptic plasticity|
|calcium ion transmembrane transport|
|receptor complex|
|regulation of peptide hormone secretion|
|regulation of heart contraction|
|calcium ion transport|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|cognition|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|protein homooligomerization|
|response to metal ion|
|neuronal cell body|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|protein complex oligomerization|
|response to inorganic substance|
|regulation of hormone levels|
|sensory perception of chemical stimulus|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|behavior|
|response to wounding|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|nucleolus|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|sensory perception|
|endoplasmic reticulum|
|regulation of protein localization|
|cell activation|
|chemical homeostasis|
|transmembrane transport|
|G protein-coupled receptor signaling pathway|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|protein-containing complex assembly|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sox7|SOX7]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITPR3 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>