======= ITSN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITSN1
  * **<color #00a2e8>Official Name</color>**: intersectin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6453|6453]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15811|Q15811]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITSN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITSN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGEF|
|C2|
|SH3 1|
|SH3 2|
|efhand 3|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|presynaptic endocytic zone|
|positive regulation of caveolin-mediated endocytosis|
|postsynaptic actin cytoskeleton|
|regulation of modification of postsynaptic actin cytoskeleton|
|kinase activator activity|
|regulation of caveolin-mediated endocytosis|
|regulation of modification of postsynaptic structure|
|positive regulation of growth hormone secretion|
|regulation of modification of synaptic structure|
|regulation of growth hormone secretion|
|apical dendrite|
|proline-rich region binding|
|calyx of Held|
|positive regulation of dendritic spine development|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|molecular adaptor activity|
|synaptic vesicle recycling|
|clathrin-coated pit|
|endocytic vesicle|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|ephrin receptor signaling pathway|
|positive regulation of peptide hormone secretion|
|positive regulation of endocytosis|
|guanyl-nucleotide exchange factor activity|
|recycling endosome|
|synaptic vesicle cycle|
|positive regulation of hormone secretion|
|vesicle-mediated transport in synapse|
|regulation of Rho protein signal transduction|
|negative regulation of neuron apoptotic process|
|dendritic spine|
|regulation of dendrite development|
|positive regulation of protein kinase B signaling|
|nuclear envelope|
|lamellipodium|
|regulation of endocytosis|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of peptide hormone secretion|
|regulation of synapse organization|
|regulation of protein kinase B signaling|
|regulation of synapse structure or activity|
|regulation of Ras protein signal transduction|
|regulation of hormone secretion|
|positive regulation of neuron projection development|
|positive regulation of peptide secretion|
|regulation of neuron death|
|small GTPase mediated signal transduction|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|positive regulation of neurogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|positive regulation of kinase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|viral process|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of peptide transport|
|brain development|
|regulation of secretion by cell|
|head development|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|membrane organization|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|protein transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.91|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.72|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6521
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITSN1 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>