======= ITSN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITSN2
  * **<color #00a2e8>Official Name</color>**: intersectin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50618|50618]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZM3|Q9NZM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITSN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITSN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604464|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170, ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|efhand 3|
|SH3 1|
|RhoGEF|
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of dendrite extension|
|regulation of dendrite extension|
|SH3/SH2 adaptor activity|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of Rho protein signal transduction|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of Ras protein signal transduction|
|positive regulation of growth|
|positive regulation of neuron projection development|
|regulation of developmental growth|
|regulation of small GTPase mediated signal transduction|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of cell growth|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|centrosome|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|endocytosis|
|regulation of neuron differentiation|
|regulation of growth|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|calcium ion binding|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.19|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.87|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.79|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.76|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.73|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.7|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.79|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.8|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.84|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sh3gl1|SH3GL1]]|0.52|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12667
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITSN2 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>