======= JAK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JAK1
  * **<color #00a2e8>Official Name</color>**: Janus kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3716|3716]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23458|P23458]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JAK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JAK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147795|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:7615558}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCR5 chemokine receptor binding|
|cellular response to interleukin-21|
|interleukin-21-mediated signaling pathway|
|response to interleukin-21|
|growth hormone receptor binding|
|interleukin-9-mediated signaling pathway|
|cellular response to interleukin-9|
|response to interleukin-9|
|interleukin-27-mediated signaling pathway|
|interleukin-2-mediated signaling pathway|
|interleukin-35-mediated signaling pathway|
|cellular response to interleukin-2|
|response to interleukin-2|
|interleukin-15-mediated signaling pathway|
|cellular response to interleukin-15|
|response to interleukin-15|
|interleukin-6-mediated signaling pathway|
|interleukin-7-mediated signaling pathway|
|regulation of response to interferon-gamma|
|regulation of interferon-gamma-mediated signaling pathway|
|response to interleukin-7|
|cellular response to interleukin-7|
|cellular response to interleukin-6|
|response to interleukin-6|
|positive regulation of sprouting angiogenesis|
|interleukin-12-mediated signaling pathway|
|non-membrane spanning protein tyrosine kinase activity|
|cellular response to interleukin-12|
|response to interleukin-12|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|regulation of sprouting angiogenesis|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|protein phosphatase binding|
|protein tyrosine kinase activity|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|cellular response to interferon-gamma|
|positive regulation of angiogenesis|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|response to interferon-gamma|
|positive regulation of vasculature development|
|endosome|
|regulation of angiogenesis|
|ubiquitin protein ligase binding|
|response to antibiotic|
|regulation of vasculature development|
|cytoskeleton|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|focal adhesion|
|regulation of innate immune response|
|regulation of response to biotic stimulus|
|cytokine-mediated signaling pathway|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|peptidyl-amino acid modification|
|defense response to other organism|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of response to stress|
|ATP binding|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.505|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JAK1 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>