======= JAM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JAM3
  * **<color #00a2e8>Official Name</color>**: junctional adhesion molecule 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83700|83700]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BX67|Q9BX67]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JAM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JAM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606871|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|ig|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of actin cytoskeleton organization by cell-cell adhesion|
|myeloid progenitor cell differentiation|
|paranodal junction|
|neutrophil homeostasis|
|Schmidt-Lanterman incisure|
|leukocyte migration involved in inflammatory response|
|cell-cell contact zone|
|axon regeneration|
|desmosome|
|regulation of neutrophil chemotaxis|
|neuron projection regeneration|
|regulation of neutrophil migration|
|regulation of granulocyte chemotaxis|
|response to axon injury|
|transmission of nerve impulse|
|leukocyte homeostasis|
|hematopoietic progenitor cell differentiation|
|myelination|
|myeloid cell homeostasis|
|axon ensheathment|
|ensheathment of neurons|
|regulation of leukocyte chemotaxis|
|establishment of cell polarity|
|bicellular tight junction|
|cell-matrix adhesion|
|integrin binding|
|multicellular organismal signaling|
|spermatid development|
|regeneration|
|spermatid differentiation|
|cell-substrate adhesion|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|homeostasis of number of cells|
|regulation of chemotaxis|
|germ cell development|
|angiogenesis|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|cellular process involved in reproduction in multicellular organism|
|leukocyte migration|
|extracellular structure organization|
|regulation of actin filament-based process|
|blood vessel morphogenesis|
|axon development|
|blood vessel development|
|protein heterodimerization activity|
|inflammatory response|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|regulation of cytoskeleton organization|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|response to wounding|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|immune system development|
|tube morphogenesis|
|neuron projection development|
|developmental process involved in reproduction|
|gamete generation|
|neuron development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|Golgi apparatus|
|multi-organism reproductive process|
|regulation of cellular component movement|
|neuron differentiation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|locomotion|
|defense response|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|cellular response to stress|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.15|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.1|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.82|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12221
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JAM3 Expression in NALM6 Cells: 2.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>