======= JHDM1D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDM7A
  * **<color #00a2e8>Official Name</color>**: lysine demethylase 7A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80853|80853]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZMT4|Q6ZMT4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JHDM1D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JHDM1D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. {ECO:0000269|PubMed:20023638, ECO:0000269|PubMed:20194436, ECO:0000269|PubMed:20622853}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|JmjC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H4-K20 demethylation|
|histone demethylase activity (H4-K20 specific)|
|histone demethylase activity (H3-K27 specific)|
|histone H3-K27 demethylation|
|histone demethylase activity (H3-K36 specific)|
|histone H3-K36 demethylation|
|histone demethylase activity (H3-K9 specific)|
|histone H3-K9 demethylation|
|2-oxoglutarate-dependent dioxygenase activity|
|histone lysine demethylation|
|histone demethylation|
|protein dealkylation|
|protein demethylation|
|methylated histone binding|
|demethylation|
|midbrain development|
|iron ion binding|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|brain development|
|head development|
|zinc ion binding|
|nucleolus|
|oxidation-reduction process|
|central nervous system development|
|chromosome organization|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.77|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.82|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.03|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.12|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JHDM1D Expression in NALM6 Cells: 3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>