======= JTB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JTB
  * **<color #00a2e8>Official Name</color>**: jumping translocation breakpoint
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10899|10899]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76095|O76095]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JTB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JTB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250, ECO:0000269|PubMed:21225229}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|JTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic cytokinesis|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|spindle|
|midbody|
|protein kinase binding|
|centrosome|
|cell division|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|mitotic cell cycle process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|regulation of protein kinase activity|
|regulation of kinase activity|
|apoptotic process|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|cell cycle|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.7|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.59|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.55|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.52|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.46|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.33|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.28|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.25|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.24|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.17|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.11|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.05|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.04|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.04|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.03|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.96|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.89|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.88|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.83|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.82|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.81|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gpr107|GPR107]]|0.653|
|[[:human genes:a:arl1|ARL1]]|0.606|
|[[:human genes:z:zfat|ZFAT]]|0.548|
|[[:human genes:a:arfrp1|ARFRP1]]|0.451|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.435|
|[[:human genes:c:cog5|COG5]]|0.427|
|[[:human genes:s:slc5a3|SLC5A3]]|0.422|
|[[:human genes:t:tssc1|TSSC1]]|0.414|
|[[:human genes:m:mbtps1|MBTPS1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2531
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JTB Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>