======= JUP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JUP
  * **<color #00a2e8>Official Name</color>**: junction plakoglobin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3728|3728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14923|P14923]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=JUP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20JUP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173325|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of cell wall|
|gamma-catenin-TCF7L2 complex|
|desmosome assembly|
|endothelial cell-cell adhesion|
|cellular response to indole-3-methanol|
|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|
|response to indole-3-methanol|
|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|
|cardiac muscle cell-cardiac muscle cell adhesion|
|zonula adherens|
|hemidesmosome|
|cytoskeletal anchoring at plasma membrane|
|alpha-catenin binding|
|fascia adherens|
|desmosome organization|
|bundle of His cell to Purkinje myocyte communication|
|epithelial cell-cell adhesion|
|regulation of ventricular cardiac muscle cell action potential|
|apicolateral plasma membrane|
|desmosome|
|nuclear hormone receptor binding|
|regulation of cardiac muscle cell action potential|
|catenin complex|
|negative regulation of blood vessel endothelial cell migration|
|heterotypic cell-cell adhesion|
|positive regulation of protein import into nucleus|
|regulation of cardiac muscle cell contraction|
|regulation of heart rate by cardiac conduction|
|positive regulation of protein import|
|regulation of actin filament-based movement|
|detection of mechanical stimulus|
|protein-DNA complex|
|cell communication involved in cardiac conduction|
|intercalated disc|
|negative regulation of endothelial cell migration|
|regulation of action potential|
|positive regulation of cell-matrix adhesion|
|cytoplasmic side of plasma membrane|
|regulation of protein import into nucleus|
|lateral plasma membrane|
|cell adhesion molecule binding|
|regulation of protein import|
|homotypic cell-cell adhesion|
|specific granule lumen|
|positive regulation of nucleocytoplasmic transport|
|cornified envelope|
|negative regulation of epithelial cell migration|
|maintenance of protein location in cell|
|positive regulation of protein localization to nucleus|
|regulation of cardiac muscle contraction|
|adherens junction organization|
|cellular response to alcohol|
|protein phosphatase binding|
|regulation of blood vessel endothelial cell migration|
|regulation of striated muscle contraction|
|cardiac conduction|
|response to antineoplastic agent|
|maintenance of location in cell|
|regulation of heart rate|
|cell-cell junction assembly|
|cell-cell adherens junction|
|regulation of nucleocytoplasmic transport|
|maintenance of protein location|
|protein heterooligomerization|
|cornification|
|regulation of cell-matrix adhesion|
|regulation of protein localization to nucleus|
|intermediate filament|
|detection of external stimulus|
|positive regulation of cell-substrate adhesion|
|detection of abiotic stimulus|
|ficolin-1-rich granule lumen|
|Z disc|
|multicellular organismal signaling|
|cell-cell junction organization|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of intracellular protein transport|
|regulation of endothelial cell migration|
|regulation of muscle contraction|
|maintenance of location|
|positive regulation of angiogenesis|
|cell junction assembly|
|cell-cell junction|
|positive regulation of Wnt signaling pathway|
|protein localization to plasma membrane|
|positive regulation of vasculature development|
|structural molecule activity|
|positive regulation of intracellular transport|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|cell junction organization|
|actin cytoskeleton|
|regulation of epithelial cell migration|
|keratinization|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|response to alcohol|
|regulation of muscle system process|
|regulation of heart contraction|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of cell motility|
|keratinocyte differentiation|
|regulation of canonical Wnt signaling pathway|
|transcription coactivator activity|
|regulation of angiogenesis|
|regulation of blood circulation|
|negative regulation of cellular component movement|
|cadherin binding|
|epidermal cell differentiation|
|regulation of vasculature development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|regulation of Wnt signaling pathway|
|cytoskeleton|
|skin development|
|regulation of actin filament-based process|
|positive regulation of cell adhesion|
|cellular response to drug|
|epidermis development|
|focal adhesion|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|regulation of membrane potential|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|protein localization to membrane|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|myeloid leukocyte activation|
|regulation of system process|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular response to nitrogen compound|
|regulation of cell adhesion|
|epithelial cell differentiation|
|detection of stimulus|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|immune effector process|
|cytoskeleton organization|
|epithelium development|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|locomotion|
|positive regulation of developmental process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.73|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|7.01|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|7.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lef1|LEF1]]|0.494|
|[[:human genes:c:ctnnb1|CTNNB1]]|0.465|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13111
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='JUP Expression in NALM6 Cells: 7.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>