======= KALRN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KALRN
  * **<color #00a2e8>Official Name</color>**: kalirin RhoGEF kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8997|8997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60229|O60229]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KALRN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KALRN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604605|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. {ECO:0000269|PubMed:10023074}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spectrin|
|I-set|
|Pkinase|
|RhoGEF|
|V-set|
|fn3|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of growth hormone secretion|
|habituation|
|nonassociative learning|
|maternal process involved in parturition|
|parental behavior|
|regulation of growth hormone secretion|
|maternal behavior|
|parturition|
|positive regulation of dendritic spine morphogenesis|
|reproductive behavior|
|positive regulation of dendrite morphogenesis|
|neuromuscular junction development|
|positive regulation of dendritic spine development|
|regulation of dendritic spine morphogenesis|
|negative regulation of peptide hormone secretion|
|lactation|
|social behavior|
|intraspecies interaction between organisms|
|negative regulation of hormone secretion|
|multi-organism behavior|
|Rho guanyl-nucleotide exchange factor activity|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|body fluid secretion|
|adult locomotory behavior|
|ephrin receptor signaling pathway|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|guanyl-nucleotide exchange factor activity|
|memory|
|mammary gland development|
|negative regulation of peptide secretion|
|regulation of Rho protein signal transduction|
|adult behavior|
|learning|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|locomotory behavior|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|actin cytoskeleton|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|regulation of Ras protein signal transduction|
|learning or memory|
|regulation of hormone secretion|
|synapse organization|
|positive regulation of neuron projection development|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of small GTPase mediated signal transduction|
|protein serine/threonine kinase activity|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|gland development|
|positive regulation of GTPase activity|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|secretion|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.07|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.75|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8480
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KALRN Expression in NALM6 Cells: 2.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>