======= KAT2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KAT2A
  * **<color #00a2e8>Official Name</color>**: lysine acetyltransferase 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2648|2648]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92830|Q92830]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KAT2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KAT2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602301|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as a acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307). {ECO:0000250|UniProtKB:Q9JHD2, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:29174768, ECO:0000269|PubMed:29211711}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCAF N|
|Bromodomain|
|Acetyltransf 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone succinyltransferase activity|
|histone acetyltransferase activity (H4-K12 specific)|
|alpha-tubulin acetylation|
|histone H3-K14 acetylation|
|H3 histone acetyltransferase activity|
|histone succinylation|
|protein succinylation|
|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|
|peptide-lysine-N-acetyltransferase activity|
|oxoglutarate dehydrogenase complex|
|histone H4-K12 acetylation|
|negative regulation of centriole replication|
|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|
|intracellular distribution of mitochondria|
|STAGA complex|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|negative regulation of centrosome duplication|
|positive regulation of gluconeogenesis|
|transcription factor TFTC complex|
|negative regulation of centrosome cycle|
|Ada2/Gcn5/Ada3 transcription activator complex|
|mitochondrion distribution|
|positive regulation of cardiac muscle cell differentiation|
|regulation of centriole replication|
|histone deubiquitination|
|positive regulation of cardiocyte differentiation|
|positive regulation of histone acetylation|
|regulation of regulatory T cell differentiation|
|long-term memory|
|positive regulation of peptidyl-lysine acetylation|
|regulation of cardiac muscle cell differentiation|
|negative regulation of organelle assembly|
|positive regulation of glucose metabolic process|
|positive regulation of protein acetylation|
|regulation of centrosome duplication|
|positive regulation of cardiac muscle tissue development|
|regulation of gluconeogenesis|
|mitochondrion localization|
|histone H3 acetylation|
|histone acetyltransferase activity|
|cellular response to nerve growth factor stimulus|
|regulation of cardiocyte differentiation|
|response to nerve growth factor|
|histone H4 acetylation|
|regulation of histone acetylation|
|regulation of centrosome cycle|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of striated muscle cell differentiation|
|regulation of peptidyl-lysine acetylation|
|positive regulation of gene expression, epigenetic|
|somitogenesis|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|regulation of protein acetylation|
|mitotic spindle|
|regulation of cardiac muscle tissue development|
|positive regulation of carbohydrate metabolic process|
|somite development|
|multicellular organism growth|
|protein phosphatase binding|
|midbrain development|
|positive regulation of muscle cell differentiation|
|positive regulation of histone modification|
|neural tube closure|
|tube closure|
|regulation of carbohydrate biosynthetic process|
|segmentation|
|primary neural tube formation|
|regulation of striated muscle cell differentiation|
|positive regulation of chromatin organization|
|neural tube formation|
|histone deacetylase binding|
|metencephalon development|
|regulation of glucose metabolic process|
|histone acetylation|
|memory|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|embryonic epithelial tube formation|
|epithelial tube formation|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of small molecule metabolic process|
|regulation of T cell differentiation|
|negative regulation of cytoskeleton organization|
|regulation of cellular carbohydrate metabolic process|
|protein acetylation|
|morphogenesis of embryonic epithelium|
|regulation of histone modification|
|tube formation|
|cytokine production|
|hindbrain development|
|regulation of muscle cell differentiation|
|neural tube development|
|chromatin remodeling|
|regulation of lymphocyte differentiation|
|positive regulation of chromosome organization|
|limb development|
|appendage development|
|protein acylation|
|regulation of synaptic plasticity|
|regulation of microtubule cytoskeleton organization|
|regulation of chromatin organization|
|regulation of carbohydrate metabolic process|
|anterior/posterior pattern specification|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|cellular response to tumor necrosis factor|
|telencephalon development|
|learning or memory|
|response to tumor necrosis factor|
|regulation of leukocyte differentiation|
|protein deubiquitination|
|transcription coactivator activity|
|regulation of protein stability|
|protein modification by small protein removal|
|cognition|
|epithelial tube morphogenesis|
|peptidyl-lysine modification|
|regulation of T cell activation|
|negative regulation of cell cycle process|
|regionalization|
|transcription factor binding|
|regulation of chromosome organization|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|in utero embryonic development|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|growth|
|chromatin binding|
|regulation of small molecule metabolic process|
|morphogenesis of an epithelium|
|pattern specification process|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|regulation of hemopoiesis|
|centrosome|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|heart development|
|response to growth factor|
|response to extracellular stimulus|
|regulation of cytoskeleton organization|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|negative regulation of cell cycle|
|organelle localization|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|chromatin organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|brain development|
|regulation of cell cycle process|
|head development|
|symbiotic process|
|interspecies interaction between organisms|
|tube development|
|circulatory system development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|chromosome organization|
|response to cytokine|
|epithelium development|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.2|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.99|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.96|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.95|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.86|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.01|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.17|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.49|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.74|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tada2b|TADA2B]]|0.556|
|[[:human genes:t:tada3|TADA3]]|0.532|
|[[:human genes:t:taf5l|TAF5L]]|0.521|
|[[:human genes:s:supt7l|SUPT7L]]|0.509|
|[[:human genes:a:atxn7|ATXN7]]|0.468|
|[[:human genes:b:brpf1|BRPF1]]|0.462|
|[[:human genes:t:taf6l|TAF6L]]|0.452|
|[[:human genes:u:usp22|USP22]]|0.447|
|[[:human genes:z:zmiz1|ZMIZ1]]|0.43|
|[[:human genes:z:znf592|ZNF592]]|0.426|
|[[:human genes:m:med13l|MED13L]]|0.423|
|[[:human genes:g:gltscr1|GLTSCR1]]|0.417|
|[[:human genes:m:med13|MED13]]|0.415|
|[[:human genes:a:atxn7l3|ATXN7L3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1386
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KAT2A Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>