======= KAT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KAT7
  * **<color #00a2e8>Official Name</color>**: lysine acetyltransferase 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11143|11143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95251|O95251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KAT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KAT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription. {ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18832067}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MOZ SAS|
|zf-C2HC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to dithiothreitol|
|response to anisomycin|
|response to actinomycin D|
|response to sorbitol|
|histone H4-K12 acetylation|
|positive regulation of histone H4 acetylation|
|H4 histone acetyltransferase activity|
|response to hydroxyurea|
|regulation of histone H4 acetylation|
|histone H4-K5 acetylation|
|response to antimetabolite|
|histone H4-K8 acetylation|
|histone H4-K16 acetylation|
|DNA replication origin binding|
|histone acetyltransferase complex|
|positive regulation of histone acetylation|
|positive regulation of peptidyl-lysine acetylation|
|positive regulation of protein acetylation|
|histone H3 acetylation|
|histone acetyltransferase activity|
|histone H4 acetylation|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|regulation of protein acetylation|
|positive regulation of protein localization to nucleus|
|positive regulation of histone modification|
|response to antineoplastic agent|
|positive regulation of chromatin organization|
|histone acetylation|
|regulation of protein localization to nucleus|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|stress-activated protein kinase signaling cascade|
|protein acetylation|
|regulation of histone modification|
|response to carbohydrate|
|positive regulation of chromosome organization|
|protein acylation|
|regulation of chromatin organization|
|DNA replication|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|response to antibiotic|
|peptidyl-lysine modification|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|histone modification|
|covalent chromatin modification|
|response to peptide|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|chromatin organization|
|zinc ion binding|
|nucleolus|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-3.02|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-3.02|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.92|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.67|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.58|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.54|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.51|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.48|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.38|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.3|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.28|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.24|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.22|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.12|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.08|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.07|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.05|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.99|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.97|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.93|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.93|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.87|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.85|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.81|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.8|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.79|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.78|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.76|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.74|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.7|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.71|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.76|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.99|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.26|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.96|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.02|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:brd1|BRD1]]|0.591|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KAT7 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>