======= KCNAB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNAB1
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily A member regulatory beta subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7881|7881]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14722|Q14722]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNAB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNAB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aldo ket red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proximal dendrite|
|potassium channel complex|
|diaphragm development|
|juxtaparanode region of axon|
|negative regulation of delayed rectifier potassium channel activity|
|aldo-keto reductase (NADP) activity|
|negative regulation of voltage-gated potassium channel activity|
|NADPH binding|
|regulation of delayed rectifier potassium channel activity|
|negative regulation of potassium ion transmembrane transporter activity|
|negative regulation of potassium ion transmembrane transport|
|dendrite cytoplasm|
|negative regulation of potassium ion transport|
|myoblast differentiation|
|potassium channel regulator activity|
|negative regulation of cation channel activity|
|regulation of potassium ion transmembrane transporter activity|
|voltage-gated potassium channel activity|
|extrinsic component of cytoplasmic side of plasma membrane|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|negative regulation of transmembrane transport|
|skeletal muscle tissue development|
|ion channel binding|
|skeletal muscle organ development|
|perikaryon|
|negative regulation of ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|respiratory system development|
|protein domain specific binding|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|cognition|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|heart development|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|brain development|
|head development|
|cation transport|
|circulatory system development|
|ion transmembrane transport|
|oxidation-reduction process|
|central nervous system development|
|negative regulation of molecular function|
|transmembrane transport|
|ion transport|
|nervous system process|
|tissue development|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.82|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNAB1 Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>