======= KCND3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCND3
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily D member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3752|3752]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK17|Q9UK17]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCND3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCND3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. {ECO:0000269|PubMed:10200233, ECO:0000269|PubMed:9843794}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans 2|
|DUF3399|
|K tetra|
|Ion trans|
|Shal-type|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|A-type (transient outward) potassium channel activity|
|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|
|membrane repolarization during ventricular cardiac muscle cell action potential|
|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|ventricular cardiac muscle cell membrane repolarization|
|potassium ion export across plasma membrane|
|cardiac muscle cell membrane repolarization|
|membrane repolarization during action potential|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization|
|ventricular cardiac muscle cell action potential|
|integral component of postsynaptic specialization membrane|
|regulation of heart rate by cardiac conduction|
|export across plasma membrane|
|cardiac muscle cell action potential involved in contraction|
|cardiac muscle cell contraction|
|cardiac muscle cell action potential|
|voltage-gated potassium channel activity|
|GABA-ergic synapse|
|cardiac muscle contraction|
|voltage-gated potassium channel complex|
|heart contraction|
|actin-mediated cell contraction|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|sarcolemma|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|ion channel binding|
|multicellular organismal signaling|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of heart contraction|
|muscle contraction|
|regulation of blood circulation|
|muscle system process|
|protein homooligomerization|
|neuronal cell body|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|dendrite|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|protein complex oligomerization|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation transport|
|ion transmembrane transport|
|export from cell|
|transmembrane transport|
|ion transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.99|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.78|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.73|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.77|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.77|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.15|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.461|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12293
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCND3 Expression in NALM6 Cells: 1.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>