======= KCNJ2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNJ2
  * **<color #00a2e8>Official Name</color>**: potassium inwardly rectifying channel subfamily J member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3759|3759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63252|P63252]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNJ2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNJ2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600681|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRK|
|IRK N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of skeletal muscle contraction via regulation of action potential|
|relaxation of skeletal muscle|
|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|
|regulation of resting membrane potential|
|intrinsic component of membrane|
|regulation of skeletal muscle contraction|
|relaxation of cardiac muscle|
|cellular potassium ion homeostasis|
|membrane depolarization during cardiac muscle cell action potential|
|magnesium ion transport|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization during action potential|
|cardiac muscle cell membrane repolarization|
|inward rectifier potassium channel activity|
|relaxation of muscle|
|membrane repolarization|
|smooth endoplasmic reticulum|
|potassium ion homeostasis|
|membrane depolarization during action potential|
|regulation of membrane repolarization|
|regulation of heart rate by cardiac conduction|
|positive regulation of potassium ion transmembrane transport|
|regulation of cardiac muscle cell contraction|
|cardiac muscle cell action potential involved in contraction|
|regulation of actin filament-based movement|
|cardiac muscle cell contraction|
|potassium ion import across plasma membrane|
|T-tubule|
|intercalated disc|
|positive regulation of potassium ion transport|
|regulation of action potential|
|cardiac muscle cell action potential|
|membrane depolarization|
|rough endoplasmic reticulum|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|cellular response to mechanical stimulus|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|heart contraction|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|protein homotetramerization|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|import across plasma membrane|
|regulation of heart rate|
|heart process|
|cellular monovalent inorganic cation homeostasis|
|striated muscle contraction|
|actin filament-based movement|
|multicellular organismal signaling|
|monovalent inorganic cation homeostasis|
|positive regulation of cation transmembrane transport|
|dendritic spine|
|protein tetramerization|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|positive regulation of transmembrane transport|
|response to mechanical stimulus|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle contraction|
|positive regulation of ion transport|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|protein homooligomerization|
|neuronal cell body|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|protein complex oligomerization|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|identical protein binding|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.96|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.29|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.93|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.85|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.92|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.93|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.02|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|2.2|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.26|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.98|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|3.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10948
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNJ2 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>