======= KCNMA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNMA1
  * **<color #00a2e8>Official Name</color>**: potassium calcium-activated channel subfamily M alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3778|3778]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12791|Q12791]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNMA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNMA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|Ion trans 2|
|BK channel a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|smooth muscle contraction involved in micturition|
|large conductance calcium-activated potassium channel activity|
|response to carbon monoxide|
|negative regulation of cell volume|
|urinary bladder smooth muscle contraction|
|relaxation of vascular smooth muscle|
|micturition|
|urinary tract smooth muscle contraction|
|relaxation of smooth muscle|
|outward rectifier potassium channel activity|
|cellular potassium ion homeostasis|
|negative regulation of smooth muscle contraction|
|calcium-activated potassium channel activity|
|relaxation of muscle|
|negative regulation of muscle contraction|
|cell volume homeostasis|
|potassium ion homeostasis|
|vasodilation|
|excretion|
|smooth muscle contraction|
|positive regulation of blood vessel diameter|
|regulation of smooth muscle contraction|
|voltage-gated potassium channel activity|
|caveola|
|response to osmotic stress|
|voltage-gated potassium channel complex|
|cellular monovalent inorganic cation homeostasis|
|renal system process|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|monovalent inorganic cation homeostasis|
|regulation of tube size|
|response to calcium ion|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|vascular process in circulatory system|
|regulation of cell size|
|postsynaptic membrane|
|regulation of muscle system process|
|muscle contraction|
|actin binding|
|muscle system process|
|apical plasma membrane|
|response to hypoxia|
|response to decreased oxygen levels|
|response to metal ion|
|regulation of cellular component size|
|response to oxygen levels|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|response to toxic substance|
|regulation of anatomical structure size|
|response to inorganic substance|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|response to drug|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|ion transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|homeostatic process|
|regulation of cell death|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5324
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNMA1 Expression in NALM6 Cells: 1.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>