======= KCTD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCTD5
  * **<color #00a2e8>Official Name</color>**: potassium channel tetramerization domain containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54442|54442]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NXV2|Q9NXV2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCTD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCTD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|K tetra|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cullin family protein binding|
|Cul3-RING ubiquitin ligase complex|
|protein-containing complex binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|protein homooligomerization|
|proteasomal protein catabolic process|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|proteolysis|
|protein-containing complex assembly|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.01|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-3.01|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.88|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.63|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.59|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.44|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.4|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.36|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.33|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.29|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.28|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.16|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.16|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.05|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.03|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.02|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.98|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.94|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.88|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.88|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.82|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.78|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.74|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.74|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.72|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.71|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.72|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.73|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.78|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.8|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.8|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.81|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.81|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.88|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.92|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.92|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.97|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.06|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.1|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.14|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.16|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.17|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.17|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.21|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.25|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.31|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.38|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.41|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.49|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.56|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.56|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.58|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|2.59|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.68|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.69|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.76|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.77|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.81|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.85|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.86|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.97|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.97|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.99|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.03|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.06|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.1|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.11|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.23|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.25|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.36|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.92|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|4.85|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|6.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp6c|PPP6C]]|0.519|
|[[:human genes:l:lsm10|LSM10]]|0.507|
|[[:human genes:s:slc25a26|SLC25A26]]|0.505|
|[[:human genes:b:bak1|BAK1]]|0.499|
|[[:human genes:l:lztr1|LZTR1]]|0.485|
|[[:human genes:r:romo1|ROMO1]]|0.485|
|[[:human genes:s:srp14|SRP14]]|0.464|
|[[:human genes:e:eny2|ENY2]]|0.461|
|[[:human genes:n:nf1|NF1]]|0.458|
|[[:human genes:t:triap1|TRIAP1]]|0.45|
|[[:human genes:p:plaa|PLAA]]|0.448|
|[[:human genes:r:rpia|RPIA]]|0.445|
|[[:human genes:a:alg1|ALG1]]|0.443|
|[[:human genes:c:casp9|CASP9]]|0.442|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.441|
|[[:human genes:p:pmm2|PMM2]]|0.439|
|[[:human genes:v:vdac2|VDAC2]]|0.437|
|[[:human genes:m:march5|MARCH5]]|0.436|
|[[:human genes:t:thg1l|THG1L]]|0.433|
|[[:human genes:d:dr1|DR1]]|0.432|
|[[:human genes:s:stau1|STAU1]]|0.426|
|[[:human genes:a:adsl|ADSL]]|0.424|
|[[:human genes:t:thoc6|THOC6]]|0.424|
|[[:human genes:p:ptpn6|PTPN6]]|0.423|
|[[:human genes:u:uhrf1|UHRF1]]|0.42|
|[[:human genes:d:dohh|DOHH]]|0.42|
|[[:human genes:c:cycs|CYCS]]|0.419|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.419|
|[[:human genes:h:hars|HARS]]|0.418|
|[[:human genes:r:rpe|RPE]]|0.418|
|[[:human genes:p:pelo|PELO]]|0.418|
|[[:human genes:f:fh|FH]]|0.415|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.414|
|[[:human genes:h:hccs|HCCS]]|0.414|
|[[:human genes:a:atic|ATIC]]|0.413|
|[[:human genes:c:camk2g|CAMK2G]]|0.411|
|[[:human genes:s:smek1|SMEK1]]|0.41|
|[[:human genes:u:uba3|UBA3]]|0.409|
|[[:human genes:f:faf2|FAF2]]|0.407|
|[[:human genes:s:serf2|SERF2]]|0.406|
|[[:human genes:u:ube2m|UBE2M]]|0.406|
|[[:human genes:a:atp2b1|ATP2B1]]|0.405|
|[[:human genes:p:phf6|PHF6]]|0.403|
|[[:human genes:a:apaf1|APAF1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4558
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCTD5 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>