======= KDM1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDM1A
  * **<color #00a2e8>Official Name</color>**: lysine demethylase 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23028|23028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60341|O60341]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDM1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDM1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609132|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SWIRM|
|DAO|
|Amino oxidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|telomeric repeat-containing RNA binding|
|histone demethylase activity (H3-dimethyl-K4 specific)|
|guanine metabolic process|
|positive regulation of histone ubiquitination|
|histone demethylase activity (H3-K4 specific)|
|MRF binding|
|negative regulation of histone H3-K4 methylation|
|DNA repair complex|
|demethylase activity|
|histone H3-K4 demethylation|
|regulation of histone ubiquitination|
|positive regulation of cell size|
|negative regulation of histone H3-K9 methylation|
|response to fungicide|
|positive regulation of chromatin binding|
|histone demethylase activity (H3-K9 specific)|
|histone H3-K9 demethylation|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|histone demethylase activity|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|alternative mRNA splicing, via spliceosome|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of histone methylation|
|purine nucleobase metabolic process|
|positive regulation of neuroblast proliferation|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of histone H3-K9 methylation|
|regulation of chromatin binding|
|telomeric DNA binding|
|regulation of histone H3-K4 methylation|
|histone lysine demethylation|
|histone demethylation|
|cellular response to gamma radiation|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|protein demethylation|
|protein dealkylation|
|regulation of neuroblast proliferation|
|negative regulation of signal transduction by p53 class mediator|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|neuron maturation|
|positive regulation of stem cell proliferation|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of histone modification|
|nucleobase metabolic process|
|androgen receptor binding|
|regulation of double-strand break repair via homologous recombination|
|positive regulation of neural precursor cell proliferation|
|cellular response to cAMP|
|negative regulation of DNA binding|
|response to gamma radiation|
|flavin adenine dinucleotide binding|
|negative regulation of chromatin organization|
|RNA polymerase II transcription factor binding|
|demethylation|
|regulation of stem cell proliferation|
|nuclear receptor transcription coactivator activity|
|regulation of histone methylation|
|p53 binding|
|cellular response to ionizing radiation|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|cellular response to UV|
|regulation of neural precursor cell proliferation|
|positive regulation of histone modification|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of cold-induced thermogenesis|
|response to cAMP|
|negative regulation of protein binding|
|regulation of DNA recombination|
|positive regulation of chromatin organization|
|nuclear chromosome, telomeric region|
|cellular response to light stimulus|
|positive regulation of protein ubiquitination|
|cerebral cortex development|
|oxidoreductase activity|
|regulation of DNA repair|
|regulation of DNA binding|
|positive regulation of protein modification by small protein conjugation or removal|
|negative regulation of chromosome organization|
|anatomical structure maturation|
|response to organophosphorus|
|response to UV|
|regulation of cold-induced thermogenesis|
|regulation of histone modification|
|response to ionizing radiation|
|muscle cell development|
|response to purine-containing compound|
|cell maturation|
|negative regulation of DNA-binding transcription factor activity|
|regulation of intrinsic apoptotic signaling pathway|
|negative regulation of binding|
|pallium development|
|positive regulation of chromosome organization|
|cellular response to radiation|
|positive regulation of binding|
|regulation of signal transduction by p53 class mediator|
|regulation of cell size|
|regulation of chromatin organization|
|regulation of protein ubiquitination|
|transcription factor complex|
|regulation of response to DNA damage stimulus|
|transcription regulatory region DNA binding|
|regulation of protein binding|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|nuclear chromatin|
|developmental maturation|
|muscle cell differentiation|
|telencephalon development|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of neuron projection development|
|blood coagulation|
|coagulation|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|hemostasis|
|RNA splicing, via transesterification reactions|
|response to antibiotic|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|transcription factor binding|
|enzyme binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|histone modification|
|purine-containing compound metabolic process|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|covalent chromatin modification|
|regulation of cellular component size|
|regulation of binding|
|positive regulation of cell projection organization|
|forebrain development|
|chromatin binding|
|RNA splicing|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|positive regulation of neurogenesis|
|muscle structure development|
|mRNA processing|
|wound healing|
|regulation of body fluid levels|
|regulation of neuron projection development|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|response to wounding|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|mRNA metabolic process|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of cellular response to stress|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.71|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.72|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.75|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.81|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.87|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.89|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.94|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.95|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.96|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.98|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.04|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.12|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.12|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.18|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.18|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.19|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.22|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.25|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.37|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.43|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.62|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.68|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rcor1|RCOR1]]|0.436|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2548
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDM1A Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>