======= KDM2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDM2B
  * **<color #00a2e8>Official Name</color>**: lysine demethylase 2B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84678|84678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHM5|Q8NHM5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDM2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDM2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609078|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
|F-box|
|zf-CXXC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|initiation of neural tube closure|
|fourth ventricle development|
|third ventricle development|
|midbrain-hindbrain boundary morphogenesis|
|positive regulation of stem cell population maintenance|
|histone demethylase activity (H3-K36 specific)|
|midbrain-hindbrain boundary development|
|histone H3-K36 demethylation|
|lateral ventricle development|
|rostrocaudal neural tube patterning|
|histone demethylase activity|
|histone H2A monoubiquitination|
|negative regulation of neural precursor cell proliferation|
|histone H2A ubiquitination|
|ventricular system development|
|embryonic camera-type eye morphogenesis|
|PcG protein complex|
|regulation of stem cell population maintenance|
|histone lysine demethylation|
|histone demethylation|
|histone monoubiquitination|
|protein dealkylation|
|protein demethylation|
|neural tube patterning|
|embryonic eye morphogenesis|
|rRNA binding|
|embryonic camera-type eye development|
|histone ubiquitination|
|protein monoubiquitination|
|demethylation|
|midbrain development|
|regulation of neural precursor cell proliferation|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|camera-type eye morphogenesis|
|embryonic epithelial tube formation|
|chromosome|
|epithelial tube formation|
|negative regulation of neuron apoptotic process|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|tube formation|
|hindbrain development|
|neural tube development|
|positive regulation of cell growth|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|anterior/posterior pattern specification|
|sensory organ morphogenesis|
|telencephalon development|
|positive regulation of growth|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|regulation of neuron death|
|camera-type eye development|
|regionalization|
|eye development|
|visual system development|
|histone modification|
|sensory system development|
|covalent chromatin modification|
|forebrain development|
|regulation of cell growth|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of growth|
|negative regulation of cell population proliferation|
|protein ubiquitination|
|gamete generation|
|chromatin organization|
|brain development|
|protein modification by small protein conjugation|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|oxidation-reduction process|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|multi-organism reproductive process|
|chromosome organization|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.32|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10740
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDM2B Expression in NALM6 Cells: 6.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>