======= KDR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDR
  * **<color #00a2e8>Official Name</color>**: kinase insert domain receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3791|3791]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35968|P35968]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|V-set|
|Pkinase|
|ig|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to hydrogen sulfide|
|response to hydrogen sulfide|
|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|
|sorting endosome|
|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|
|vascular endothelial growth factor binding|
|vascular endothelial growth factor-activated receptor activity|
|positive regulation of vasculogenesis|
|positive regulation of mitochondrial depolarization|
|positive regulation of membrane depolarization|
|regulation of vasculogenesis|
|positive regulation of endothelial cell chemotaxis|
|positive regulation of mitochondrial fission|
|positive regulation of nitric-oxide synthase biosynthetic process|
|regulation of nitric-oxide synthase biosynthetic process|
|embryonic hemopoiesis|
|vascular endothelial growth factor signaling pathway|
|positive regulation of cell migration involved in sprouting angiogenesis|
|regulation of mitochondrial depolarization|
|cell migration involved in sprouting angiogenesis|
|regulation of endothelial cell chemotaxis|
|regulation of mitochondrial fission|
|calcium-mediated signaling using intracellular calcium source|
|positive regulation of positive chemotaxis|
|positive regulation of focal adhesion assembly|
|regulation of positive chemotaxis|
|ERK1 and ERK2 cascade|
|blood vessel endothelial cell migration|
|negative regulation of endothelial cell apoptotic process|
|positive regulation of adherens junction organization|
|growth factor binding|
|peptidyl-tyrosine autophosphorylation|
|positive regulation of cell junction assembly|
|protein kinase B signaling|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|cellular response to vascular endothelial growth factor stimulus|
|Hsp90 protein binding|
|negative regulation of epithelial cell apoptotic process|
|regulation of membrane depolarization|
|regulation of endothelial cell apoptotic process|
|positive regulation of cell-matrix adhesion|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of blood vessel endothelial cell migration|
|sprouting angiogenesis|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|endothelial cell migration|
|regulation of adherens junction organization|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of macroautophagy|
|vasculogenesis|
|regulation of sprouting angiogenesis|
|regulation of mitochondrial membrane potential|
|regulation of epithelial cell apoptotic process|
|endothelial cell differentiation|
|epithelial cell migration|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|epithelium migration|
|protein tyrosine kinase activity|
|regulation of cell junction assembly|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|tissue migration|
|endothelium development|
|positive regulation of endothelial cell migration|
|regulation of cell-matrix adhesion|
|positive regulation of mitochondrion organization|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|positive regulation of cell-substrate adhesion|
|regulation of endothelial cell proliferation|
|integrin binding|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|peptidyl-tyrosine phosphorylation|
|calcium-mediated signaling|
|peptidyl-tyrosine modification|
|regulation of cell shape|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|ameboidal-type cell migration|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|protein autophosphorylation|
|receptor complex|
|cellular response to acid chemical|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|cellular response to toxic substance|
|regulation of epithelial cell migration|
|membrane raft|
|early endosome|
|endosome|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|cadherin binding|
|angiogenesis|
|regulation of vasculature development|
|regulation of autophagy|
|regulation of epithelial cell proliferation|
|second-messenger-mediated signaling|
|extracellular matrix organization|
|response to acid chemical|
|positive regulation of cellular catabolic process|
|MAPK cascade|
|extracellular structure organization|
|signal transduction by protein phosphorylation|
|positive regulation of cell adhesion|
|cellular response to drug|
|blood vessel morphogenesis|
|regulation of membrane potential|
|positive regulation of catabolic process|
|embryonic organ development|
|blood vessel development|
|regulation of cell morphogenesis|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|response to toxic substance|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|cell junction|
|positive regulation of locomotion|
|hemopoiesis|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|immune system development|
|tube morphogenesis|
|epithelial cell differentiation|
|regulation of cell adhesion|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|circulatory system development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|Golgi apparatus|
|regulation of catabolic process|
|negative regulation of cell death|
|regulation of cellular component movement|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|chemical homeostasis|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.13|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.94|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3664
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDR Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>